Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy

Sung Woo Ha, Hyun Ji Kim, Jong Sup Bae, Gui Hwa Jeong, Sung Chang Chung, Jung Guk Kim, Sun Hee Park, Yong Lim Kim, Sin Kam, In-San Kim, Bo Wan Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) is a pro-sclerotic growth factor implicated in the pathogenesis of diabetic nephropathy. βig-h3 is an extracellular matrix protein which is induced in many cells by TGF-β. This study examined urinary βig-h3 excretion in diabetic patients with elevated urinary albumin excretion and the clinical application of urinary βig-h3 as a marker of diabetic nephropathy. Urinary and serum βig-h3 levels were determined by enzyme-linked immunosorbent assay in 163 type 2 diabetic patients and 101 healthy control subjects of comparable age and weight. The ratio of urinary βig-h3 and TGF-β to creatinine was analyzed in patients with different degree of nephropathy. The βig-h3 to creatinine ratio in urine was elevated in all groups of type 2 diabetics with normoalbuminuria (101.6±9.27), microalbuminuria (120.2±14.48), and overt proteinuria (146.3±16.34), when compared with control subjects (64.8±7.14) (P<0.01). There was a positive correlation between urinary βig-h3 and TGF-β excretion rate and a positive correlation between urinary βig-h3 and albumin excretion rate (AER). These data show that urinary levels of βig-h3 are elevated in type 2 diabetic patients with nephropathy and may be used as a marker of diabetic nephropathy.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume65
Issue number2
DOIs
Publication statusPublished - 2004 Aug 1
Externally publishedYes

Fingerprint

Transforming Growth Factors
Type 2 Diabetes Mellitus
Diabetic Nephropathies
Albumins
Creatinine
Proteins
Extracellular Matrix Proteins
Proteinuria
Intercellular Signaling Peptides and Proteins
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay
Urine
Weights and Measures
Serum

Keywords

  • βig-h3
  • AER
  • albumin excretion rate
  • Diabetic nephropathy
  • TGF-β
  • transforming growth factor
  • transforming growth factor-β-induced gene-h3
  • Urinary βig-h3

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy. / Ha, Sung Woo; Kim, Hyun Ji; Bae, Jong Sup; Jeong, Gui Hwa; Chung, Sung Chang; Kim, Jung Guk; Park, Sun Hee; Kim, Yong Lim; Kam, Sin; Kim, In-San; Kim, Bo Wan.

In: Diabetes Research and Clinical Practice, Vol. 65, No. 2, 01.08.2004, p. 167-173.

Research output: Contribution to journalArticle

Ha, Sung Woo ; Kim, Hyun Ji ; Bae, Jong Sup ; Jeong, Gui Hwa ; Chung, Sung Chang ; Kim, Jung Guk ; Park, Sun Hee ; Kim, Yong Lim ; Kam, Sin ; Kim, In-San ; Kim, Bo Wan. / Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy. In: Diabetes Research and Clinical Practice. 2004 ; Vol. 65, No. 2. pp. 167-173.
@article{d0eb78c553274696b2203cf54b2c3d7a,
title = "Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy",
abstract = "Transforming growth factor-β (TGF-β) is a pro-sclerotic growth factor implicated in the pathogenesis of diabetic nephropathy. βig-h3 is an extracellular matrix protein which is induced in many cells by TGF-β. This study examined urinary βig-h3 excretion in diabetic patients with elevated urinary albumin excretion and the clinical application of urinary βig-h3 as a marker of diabetic nephropathy. Urinary and serum βig-h3 levels were determined by enzyme-linked immunosorbent assay in 163 type 2 diabetic patients and 101 healthy control subjects of comparable age and weight. The ratio of urinary βig-h3 and TGF-β to creatinine was analyzed in patients with different degree of nephropathy. The βig-h3 to creatinine ratio in urine was elevated in all groups of type 2 diabetics with normoalbuminuria (101.6±9.27), microalbuminuria (120.2±14.48), and overt proteinuria (146.3±16.34), when compared with control subjects (64.8±7.14) (P<0.01). There was a positive correlation between urinary βig-h3 and TGF-β excretion rate and a positive correlation between urinary βig-h3 and albumin excretion rate (AER). These data show that urinary levels of βig-h3 are elevated in type 2 diabetic patients with nephropathy and may be used as a marker of diabetic nephropathy.",
keywords = "βig-h3, AER, albumin excretion rate, Diabetic nephropathy, TGF-β, transforming growth factor, transforming growth factor-β-induced gene-h3, Urinary βig-h3",
author = "Ha, {Sung Woo} and Kim, {Hyun Ji} and Bae, {Jong Sup} and Jeong, {Gui Hwa} and Chung, {Sung Chang} and Kim, {Jung Guk} and Park, {Sun Hee} and Kim, {Yong Lim} and Sin Kam and In-San Kim and Kim, {Bo Wan}",
year = "2004",
month = "8",
day = "1",
doi = "10.1016/j.diabres.2004.01.007",
language = "English",
volume = "65",
pages = "167--173",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy

AU - Ha, Sung Woo

AU - Kim, Hyun Ji

AU - Bae, Jong Sup

AU - Jeong, Gui Hwa

AU - Chung, Sung Chang

AU - Kim, Jung Guk

AU - Park, Sun Hee

AU - Kim, Yong Lim

AU - Kam, Sin

AU - Kim, In-San

AU - Kim, Bo Wan

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Transforming growth factor-β (TGF-β) is a pro-sclerotic growth factor implicated in the pathogenesis of diabetic nephropathy. βig-h3 is an extracellular matrix protein which is induced in many cells by TGF-β. This study examined urinary βig-h3 excretion in diabetic patients with elevated urinary albumin excretion and the clinical application of urinary βig-h3 as a marker of diabetic nephropathy. Urinary and serum βig-h3 levels were determined by enzyme-linked immunosorbent assay in 163 type 2 diabetic patients and 101 healthy control subjects of comparable age and weight. The ratio of urinary βig-h3 and TGF-β to creatinine was analyzed in patients with different degree of nephropathy. The βig-h3 to creatinine ratio in urine was elevated in all groups of type 2 diabetics with normoalbuminuria (101.6±9.27), microalbuminuria (120.2±14.48), and overt proteinuria (146.3±16.34), when compared with control subjects (64.8±7.14) (P<0.01). There was a positive correlation between urinary βig-h3 and TGF-β excretion rate and a positive correlation between urinary βig-h3 and albumin excretion rate (AER). These data show that urinary levels of βig-h3 are elevated in type 2 diabetic patients with nephropathy and may be used as a marker of diabetic nephropathy.

AB - Transforming growth factor-β (TGF-β) is a pro-sclerotic growth factor implicated in the pathogenesis of diabetic nephropathy. βig-h3 is an extracellular matrix protein which is induced in many cells by TGF-β. This study examined urinary βig-h3 excretion in diabetic patients with elevated urinary albumin excretion and the clinical application of urinary βig-h3 as a marker of diabetic nephropathy. Urinary and serum βig-h3 levels were determined by enzyme-linked immunosorbent assay in 163 type 2 diabetic patients and 101 healthy control subjects of comparable age and weight. The ratio of urinary βig-h3 and TGF-β to creatinine was analyzed in patients with different degree of nephropathy. The βig-h3 to creatinine ratio in urine was elevated in all groups of type 2 diabetics with normoalbuminuria (101.6±9.27), microalbuminuria (120.2±14.48), and overt proteinuria (146.3±16.34), when compared with control subjects (64.8±7.14) (P<0.01). There was a positive correlation between urinary βig-h3 and TGF-β excretion rate and a positive correlation between urinary βig-h3 and albumin excretion rate (AER). These data show that urinary levels of βig-h3 are elevated in type 2 diabetic patients with nephropathy and may be used as a marker of diabetic nephropathy.

KW - βig-h3

KW - AER

KW - albumin excretion rate

KW - Diabetic nephropathy

KW - TGF-β

KW - transforming growth factor

KW - transforming growth factor-β-induced gene-h3

KW - Urinary βig-h3

UR - http://www.scopus.com/inward/record.url?scp=3042655100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042655100&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2004.01.007

DO - 10.1016/j.diabres.2004.01.007

M3 - Article

C2 - 15223229

AN - SCOPUS:3042655100

VL - 65

SP - 167

EP - 173

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 2

ER -