Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy

Sung Woo Ha, Hyun Ji Kim, Jong Sup Bae, Gui Hwa Jeong, Sung Chang Chung, Jung Guk Kim, Sun Hee Park, Yong Lim Kim, Sin Kam, In San Kim, Bo Wan Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) is a pro-sclerotic growth factor implicated in the pathogenesis of diabetic nephropathy. βig-h3 is an extracellular matrix protein which is induced in many cells by TGF-β. This study examined urinary βig-h3 excretion in diabetic patients with elevated urinary albumin excretion and the clinical application of urinary βig-h3 as a marker of diabetic nephropathy. Urinary and serum βig-h3 levels were determined by enzyme-linked immunosorbent assay in 163 type 2 diabetic patients and 101 healthy control subjects of comparable age and weight. The ratio of urinary βig-h3 and TGF-β to creatinine was analyzed in patients with different degree of nephropathy. The βig-h3 to creatinine ratio in urine was elevated in all groups of type 2 diabetics with normoalbuminuria (101.6±9.27), microalbuminuria (120.2±14.48), and overt proteinuria (146.3±16.34), when compared with control subjects (64.8±7.14) (P<0.01). There was a positive correlation between urinary βig-h3 and TGF-β excretion rate and a positive correlation between urinary βig-h3 and albumin excretion rate (AER). These data show that urinary levels of βig-h3 are elevated in type 2 diabetic patients with nephropathy and may be used as a marker of diabetic nephropathy.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume65
Issue number2
DOIs
Publication statusPublished - 2004 Aug 1

Keywords

  • AER
  • Diabetic nephropathy
  • TGF-β
  • Urinary βig-h3
  • albumin excretion rate
  • transforming growth factor
  • transforming growth factor-β-induced gene-h3
  • βig-h3

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Ha, S. W., Kim, H. J., Bae, J. S., Jeong, G. H., Chung, S. C., Kim, J. G., Park, S. H., Kim, Y. L., Kam, S., Kim, I. S., & Kim, B. W. (2004). Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy. Diabetes Research and Clinical Practice, 65(2), 167-173. https://doi.org/10.1016/j.diabres.2004.01.007