TY - JOUR
T1 - Elimination of Unreacted Acrylate Double Bonds in the Polymer Networks of Microparticles Synthesized via Flow Lithography
AU - Moon, Hyun June
AU - Ku, Minhee
AU - Roh, Yoon Ho
AU - Lee, Hyun Jee
AU - Yang, Jaemoon
AU - Bong, Ki Wan
N1 - Funding Information:
This work was supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016R1A5A1010148), the Next-Generation Biogreen 21 Program funded by Rural Development Administration of Republic of Korea (no. PJ013158), and the Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1D1A1B07046577). This research was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2017R1C1B2010867) and R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Hl17C2586).
Funding Information:
This work was supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016R1A5A1010148), the Next-Generation Biogreen 21 Program funded by Rural Development Administration of Republic of Korea (no. PJ013158), and the Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1D1A1B07046577). This research was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2017R1C1B2010867) and R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare Republic of Korea (Hl17C2586).
Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/3/10
Y1 - 2020/3/10
N2 - Flow lithography (FL), a versatile technique used to synthesize anisotropic multifunctional microparticles, has attracted substantial interest, given that the resulting particles with complex geometries and multilayered biochemical functionalities can be used in a wide variety of applications. However, after this process, there are double bonds remaining from the cross-linkable groups of monomers. The unreacted cross-linkable groups can affect the particles' biochemical properties. Here, we verify that the microparticles produced by FL contain a significant number of unreacted acrylate double bonds (UADBs), which could cause irreversible biochemical changes in the particle and pernicious effects to biological systems. We also confirm that the particles contain a considerable number of UADBs, regardless of the various synthetic (lithographic) conditions that can be used in a typical FL process. We present an effective way to eliminate a substantial amount of UADBs after synthesis by linking biochemically inert poly(ethylene glycol) based on click chemistry. We verify that eliminating UADBs by using this click chemistry approach can efficiently resolve problems, such as the occurrence of random reactions and the cytotoxicity of UADBs.
AB - Flow lithography (FL), a versatile technique used to synthesize anisotropic multifunctional microparticles, has attracted substantial interest, given that the resulting particles with complex geometries and multilayered biochemical functionalities can be used in a wide variety of applications. However, after this process, there are double bonds remaining from the cross-linkable groups of monomers. The unreacted cross-linkable groups can affect the particles' biochemical properties. Here, we verify that the microparticles produced by FL contain a significant number of unreacted acrylate double bonds (UADBs), which could cause irreversible biochemical changes in the particle and pernicious effects to biological systems. We also confirm that the particles contain a considerable number of UADBs, regardless of the various synthetic (lithographic) conditions that can be used in a typical FL process. We present an effective way to eliminate a substantial amount of UADBs after synthesis by linking biochemically inert poly(ethylene glycol) based on click chemistry. We verify that eliminating UADBs by using this click chemistry approach can efficiently resolve problems, such as the occurrence of random reactions and the cytotoxicity of UADBs.
UR - http://www.scopus.com/inward/record.url?scp=85081887723&partnerID=8YFLogxK
U2 - 10.1021/acs.langmuir.9b02737
DO - 10.1021/acs.langmuir.9b02737
M3 - Article
C2 - 32013441
AN - SCOPUS:85081887723
VL - 36
SP - 2271
EP - 2277
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 9
ER -