TY - JOUR
T1 - Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii
AU - Ito, Aiko
AU - Chai, Hee Byung
AU - Lee, Dongho
AU - Kardono, Leonardus B.S.
AU - Riswan, Soedarsono
AU - Farnsworth, Norman R.
AU - Cordell, Geoffrey A.
AU - Pezzuto, John M.
AU - Kinghorn, A. Douglas
PY - 2002/9/13
Y1 - 2002/9/13
N2 - Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.
AB - Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.
KW - Cucurbitacins
KW - Cytotoxicity
KW - Elaeocarpaceae
KW - Elaeocarpus mastersii
KW - Ellagic acid derivatives
UR - http://www.scopus.com/inward/record.url?scp=0037072492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037072492&partnerID=8YFLogxK
U2 - 10.1016/S0031-9422(02)00232-7
DO - 10.1016/S0031-9422(02)00232-7
M3 - Article
C2 - 12169311
AN - SCOPUS:0037072492
VL - 61
SP - 171
EP - 174
JO - Phytochemistry
JF - Phytochemistry
SN - 0031-9422
IS - 2
ER -