Abstract
Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 171-174 |
| Number of pages | 4 |
| Journal | Phytochemistry |
| Volume | 61 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2002 Sep 13 |
Keywords
- Cucurbitacins
- Cytotoxicity
- Elaeocarpaceae
- Elaeocarpus mastersii
- Ellagic acid derivatives
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Plant Science
- Horticulture
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Cite this
Ito, A., Chai, H. B., Lee, D., Kardono, L. B. S., Riswan, S., Farnsworth, N. R., Cordell, G. A., Pezzuto, J. M., & Kinghorn, A. D. (2002). Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. Phytochemistry, 61(2), 171-174. https://doi.org/10.1016/S0031-9422(02)00232-7