Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

Aiko Ito; Hee Byung Chai; Dongho Lee; Leonardus B.S. Kardono; Soedarsono Riswan; Norman R. Farnsworth; Geoffrey A. Cordell; John M. Pezzuto; A. Douglas Kinghorn

doi:10.1016/S0031-9422(02)00232-7

Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

Aiko Ito, Hee Byung Chai, Dongho Lee, Leonardus B.S. Kardono, Soedarsono Riswan, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

Original language	English
Pages (from-to)	171-174
Number of pages	4
Journal	Phytochemistry
Volume	61
Issue number	2
DOIs	https://doi.org/10.1016/S0031-9422(02)00232-7
Publication status	Published - 2002 Sep 13
Externally published	Yes

Keywords

Cucurbitacins
Cytotoxicity
Elaeocarpaceae
Elaeocarpus mastersii
Ellagic acid derivatives

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

Access to Document

10.1016/S0031-9422(02)00232-7

Cite this

@article{52688815588d44a8b38f830aad409629,

title = "Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii",

abstract = "Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.",

keywords = "Cucurbitacins, Cytotoxicity, Elaeocarpaceae, Elaeocarpus mastersii, Ellagic acid derivatives",

author = "Aiko Ito and Chai, {Hee Byung} and Dongho Lee and Kardono, {Leonardus B.S.} and Soedarsono Riswan and Farnsworth, {Norman R.} and Cordell, {Geoffrey A.} and Pezzuto, {John M.} and Kinghorn, {A. Douglas}",

note = "Funding Information: This investigation was supported by grant U19-CA-52956, funded by the National Cancer Institute, NIH, Bethesda, Maryland. We thank Dr. K. Fagerquist, Mass Spectrometry Facility, Department of Chemistry, University of Minnesota, Minneapolis, MN and Dr. J. Anderson, Research Resources Center, University of Illinois at Chicago for the mass spectral data. We are grateful to the Nuclear Magnetic Resonance Laboratory of the Research Resources Center, University of Illinois at Chicago, for the provision of certain NMR spectral facilities used in this investigation.",

year = "2002",

month = sep,

day = "13",

doi = "10.1016/S0031-9422(02)00232-7",

language = "English",

volume = "61",

pages = "171--174",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

AU - Ito, Aiko

AU - Chai, Hee Byung

AU - Lee, Dongho

AU - Kardono, Leonardus B.S.

AU - Riswan, Soedarsono

AU - Farnsworth, Norman R.

AU - Cordell, Geoffrey A.

AU - Pezzuto, John M.

AU - Kinghorn, A. Douglas

N1 - Funding Information: This investigation was supported by grant U19-CA-52956, funded by the National Cancer Institute, NIH, Bethesda, Maryland. We thank Dr. K. Fagerquist, Mass Spectrometry Facility, Department of Chemistry, University of Minnesota, Minneapolis, MN and Dr. J. Anderson, Research Resources Center, University of Illinois at Chicago for the mass spectral data. We are grateful to the Nuclear Magnetic Resonance Laboratory of the Research Resources Center, University of Illinois at Chicago, for the provision of certain NMR spectral facilities used in this investigation.

PY - 2002/9/13

Y1 - 2002/9/13

N2 - Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

AB - Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

KW - Cucurbitacins

KW - Cytotoxicity

KW - Elaeocarpaceae

KW - Elaeocarpus mastersii

KW - Ellagic acid derivatives

UR - http://www.scopus.com/inward/record.url?scp=0037072492&partnerID=8YFLogxK

U2 - 10.1016/S0031-9422(02)00232-7

DO - 10.1016/S0031-9422(02)00232-7

M3 - Article

C2 - 12169311

AN - SCOPUS:0037072492

VL - 61

SP - 171

EP - 174

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

IS - 2

ER -

Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this