Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

Aiko Ito; Hee Byung Chai; Dongho Lee; Leonardus B.S. Kardono; Soedarsono Riswan; Norman R. Farnsworth; Geoffrey A. Cordell; John M. Pezzuto; A. Douglas Kinghorn

doi:10.1016/S0031-9422(02)00232-7

Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

Aiko Ito, Hee Byung Chai, Dongho Lee, Leonardus B.S. Kardono, Soedarsono Riswan, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

Original language	English
Pages (from-to)	171-174
Number of pages	4
Journal	Phytochemistry
Volume	61
Issue number	2
DOIs	https://doi.org/10.1016/S0031-9422(02)00232-7
Publication status	Published - 2002 Sep 13
Externally published	Yes

Keywords

Cucurbitacins
Cytotoxicity
Elaeocarpaceae
Elaeocarpus mastersii
Ellagic acid derivatives

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. / Ito, Aiko; Chai, Hee Byung; Lee, Dongho; Kardono, Leonardus B.S.; Riswan, Soedarsono; Farnsworth, Norman R.; Cordell, Geoffrey A.; Pezzuto, John M.; Kinghorn, A. Douglas.

In: Phytochemistry, Vol. 61, No. 2, 13.09.2002, p. 171-174.

Research output: Contribution to journal › Article › peer-review

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abstract = "Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.",

keywords = "Cucurbitacins, Cytotoxicity, Elaeocarpaceae, Elaeocarpus mastersii, Ellagic acid derivatives",

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AU - Ito, Aiko

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AU - Lee, Dongho

AU - Kardono, Leonardus B.S.

AU - Riswan, Soedarsono

AU - Farnsworth, Norman R.

AU - Cordell, Geoffrey A.

AU - Pezzuto, John M.

AU - Kinghorn, A. Douglas

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