Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

Aiko Ito, Hee Byung Chai, Dongho Lee, Leonardus B S Kardono, Soedarsono Riswan, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalPhytochemistry
Volume61
Issue number2
DOIs
Publication statusPublished - 2002 Sep 13
Externally publishedYes

Fingerprint

Elaeocarpaceae
Cucurbitacins
Elaeocarpus
cucurbitacins
Ellagic Acid
ellagic acid
Bioassay
Tumors
chemical derivatives
Cells
Derivatives
Acids
Tumor Cell Line
Biological Assay
Squamous Cell Carcinoma
acids
carcinoma
mouth
bark
bioassays

Keywords

  • Cucurbitacins
  • Cytotoxicity
  • Elaeocarpaceae
  • Elaeocarpus mastersii
  • Ellagic acid derivatives

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

Cite this

Ito, A., Chai, H. B., Lee, D., Kardono, L. B. S., Riswan, S., Farnsworth, N. R., ... Kinghorn, A. D. (2002). Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. Phytochemistry, 61(2), 171-174. https://doi.org/10.1016/S0031-9422(02)00232-7

Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. / Ito, Aiko; Chai, Hee Byung; Lee, Dongho; Kardono, Leonardus B S; Riswan, Soedarsono; Farnsworth, Norman R.; Cordell, Geoffrey A.; Pezzuto, John M.; Kinghorn, A. Douglas.

In: Phytochemistry, Vol. 61, No. 2, 13.09.2002, p. 171-174.

Research output: Contribution to journalArticle

Ito, A, Chai, HB, Lee, D, Kardono, LBS, Riswan, S, Farnsworth, NR, Cordell, GA, Pezzuto, JM & Kinghorn, AD 2002, 'Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii', Phytochemistry, vol. 61, no. 2, pp. 171-174. https://doi.org/10.1016/S0031-9422(02)00232-7
Ito, Aiko ; Chai, Hee Byung ; Lee, Dongho ; Kardono, Leonardus B S ; Riswan, Soedarsono ; Farnsworth, Norman R. ; Cordell, Geoffrey A. ; Pezzuto, John M. ; Kinghorn, A. Douglas. / Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. In: Phytochemistry. 2002 ; Vol. 61, No. 2. pp. 171-174.
@article{52688815588d44a8b38f830aad409629,
title = "Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii",
abstract = "Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.",
keywords = "Cucurbitacins, Cytotoxicity, Elaeocarpaceae, Elaeocarpus mastersii, Ellagic acid derivatives",
author = "Aiko Ito and Chai, {Hee Byung} and Dongho Lee and Kardono, {Leonardus B S} and Soedarsono Riswan and Farnsworth, {Norman R.} and Cordell, {Geoffrey A.} and Pezzuto, {John M.} and Kinghorn, {A. Douglas}",
year = "2002",
month = "9",
day = "13",
doi = "10.1016/S0031-9422(02)00232-7",
language = "English",
volume = "61",
pages = "171--174",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

AU - Ito, Aiko

AU - Chai, Hee Byung

AU - Lee, Dongho

AU - Kardono, Leonardus B S

AU - Riswan, Soedarsono

AU - Farnsworth, Norman R.

AU - Cordell, Geoffrey A.

AU - Pezzuto, John M.

AU - Kinghorn, A. Douglas

PY - 2002/9/13

Y1 - 2002/9/13

N2 - Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

AB - Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

KW - Cucurbitacins

KW - Cytotoxicity

KW - Elaeocarpaceae

KW - Elaeocarpus mastersii

KW - Ellagic acid derivatives

UR - http://www.scopus.com/inward/record.url?scp=0037072492&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037072492&partnerID=8YFLogxK

U2 - 10.1016/S0031-9422(02)00232-7

DO - 10.1016/S0031-9422(02)00232-7

M3 - Article

VL - 61

SP - 171

EP - 174

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

IS - 2

ER -