Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

Aiko Ito, Hee Byung Chai, Dongho Lee, Leonardus B.S. Kardono, Soedarsono Riswan, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalPhytochemistry
Volume61
Issue number2
DOIs
Publication statusPublished - 2002 Sep 13

Keywords

  • Cucurbitacins
  • Cytotoxicity
  • Elaeocarpaceae
  • Elaeocarpus mastersii
  • Ellagic acid derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Fingerprint Dive into the research topics of 'Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii'. Together they form a unique fingerprint.

  • Cite this

    Ito, A., Chai, H. B., Lee, D., Kardono, L. B. S., Riswan, S., Farnsworth, N. R., Cordell, G. A., Pezzuto, J. M., & Kinghorn, A. D. (2002). Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. Phytochemistry, 61(2), 171-174. https://doi.org/10.1016/S0031-9422(02)00232-7