TY - JOUR
T1 - Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii
AU - Ito, Aiko
AU - Chai, Hee Byung
AU - Lee, Dongho
AU - Kardono, Leonardus B.S.
AU - Riswan, Soedarsono
AU - Farnsworth, Norman R.
AU - Cordell, Geoffrey A.
AU - Pezzuto, John M.
AU - Kinghorn, A. Douglas
N1 - Funding Information:
This investigation was supported by grant U19-CA-52956, funded by the National Cancer Institute, NIH, Bethesda, Maryland. We thank Dr. K. Fagerquist, Mass Spectrometry Facility, Department of Chemistry, University of Minnesota, Minneapolis, MN and Dr. J. Anderson, Research Resources Center, University of Illinois at Chicago for the mass spectral data. We are grateful to the Nuclear Magnetic Resonance Laboratory of the Research Resources Center, University of Illinois at Chicago, for the provision of certain NMR spectral facilities used in this investigation.
PY - 2002/9/13
Y1 - 2002/9/13
N2 - Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.
AB - Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.
KW - Cucurbitacins
KW - Cytotoxicity
KW - Elaeocarpaceae
KW - Elaeocarpus mastersii
KW - Ellagic acid derivatives
UR - http://www.scopus.com/inward/record.url?scp=0037072492&partnerID=8YFLogxK
U2 - 10.1016/S0031-9422(02)00232-7
DO - 10.1016/S0031-9422(02)00232-7
M3 - Article
C2 - 12169311
AN - SCOPUS:0037072492
VL - 61
SP - 171
EP - 174
JO - Phytochemistry
JF - Phytochemistry
SN - 0031-9422
IS - 2
ER -