Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

Aiko Ito, Hee Byung Chai, Dongho Lee, Leonardus B S Kardono, Soedarsono Riswan, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′-O-methylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (1) and 4,4′-O-dimethylellagic acid 3-(2″,3″-di-O-acetyl)-α-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalPhytochemistry
Volume61
Issue number2
DOIs
Publication statusPublished - 2002 Sep 13
Externally publishedYes

Fingerprint

Elaeocarpaceae
Cucurbitacins
Elaeocarpus
cucurbitacins
Ellagic Acid
ellagic acid
Bioassay
Tumors
chemical derivatives
Cells
Derivatives
Acids
Tumor Cell Line
Biological Assay
Squamous Cell Carcinoma
acids
carcinoma
mouth
bark
bioassays

Keywords

  • Cucurbitacins
  • Cytotoxicity
  • Elaeocarpaceae
  • Elaeocarpus mastersii
  • Ellagic acid derivatives

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

Cite this

Ito, A., Chai, H. B., Lee, D., Kardono, L. B. S., Riswan, S., Farnsworth, N. R., ... Kinghorn, A. D. (2002). Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. Phytochemistry, 61(2), 171-174. https://doi.org/10.1016/S0031-9422(02)00232-7

Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. / Ito, Aiko; Chai, Hee Byung; Lee, Dongho; Kardono, Leonardus B S; Riswan, Soedarsono; Farnsworth, Norman R.; Cordell, Geoffrey A.; Pezzuto, John M.; Kinghorn, A. Douglas.

In: Phytochemistry, Vol. 61, No. 2, 13.09.2002, p. 171-174.

Research output: Contribution to journal › Article

Ito, A, Chai, HB, Lee, D, Kardono, LBS, Riswan, S, Farnsworth, NR, Cordell, GA, Pezzuto, JM & Kinghorn, AD 2002, 'Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii', Phytochemistry, vol. 61, no. 2, pp. 171-174. https://doi.org/10.1016/S0031-9422(02)00232-7
Ito A, Chai HB, Lee D, Kardono LBS, Riswan S, Farnsworth NR et al. Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. Phytochemistry. 2002 Sep 13;61(2):171-174. https://doi.org/10.1016/S0031-9422(02)00232-7
Ito, Aiko ; Chai, Hee Byung ; Lee, Dongho ; Kardono, Leonardus B S ; Riswan, Soedarsono ; Farnsworth, Norman R. ; Cordell, Geoffrey A. ; Pezzuto, John M. ; Kinghorn, A. Douglas. / Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. In: Phytochemistry. 2002 ; Vol. 61, No. 2. pp. 171-174.
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