Embryonal neuromesodermal progenitors for caudal central nervous system and tissue development

Mohammed R. Shaker, Ju Hyun Lee, Woong Sun

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Neuromesodermal progenitors (NMPs) constitute a bipotent cell population that generates a wide variety of trunk cell and tissue types during embryonic development. Derivatives of NMPs include both mesodermal lineage cells such as muscles and vertebral bones, and neural lineage cells such as neural crests and central nervous system neurons. Such diverse lineage potential combined with a limited capacity for self-renewal, which persists during axial elongation, demonstrates that NMPs are a major source of trunk tissues. This review describes the identification and characterization of NMPs across multiple species. We also discuss key cellular and molecular steps for generating neural and mesodermal cells for building up the elongating trunk tissue.

Original languageEnglish
Pages (from-to)359-366
Number of pages8
JournalJournal of Korean Neurosurgical Society
Volume64
Issue number3
DOIs
Publication statusPublished - 2021

Keywords

  • Axial elongation
  • Neural tube
  • Neuromesodermal progenitors
  • Neurulation
  • Spinal cord development

ASJC Scopus subject areas

  • Surgery
  • Neuroscience(all)
  • Clinical Neurology

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