TY - JOUR
T1 - Emerging 2D material-based nanocarrier for cancer therapy beyond graphene
AU - Wang, Yingwei
AU - Qiu, Meng
AU - Won, Miae
AU - Jung, Eugeine
AU - Fan, Taojian
AU - Xie, Ni
AU - Chi, Sung Gil
AU - Zhang, Han
AU - Kim, Jong Seung
N1 - Funding Information:
This research was supported in partially by the National Natural Science Fund, China (Grant No. 61875138, 61435010, 11904239 and 6181101252), and Science and Technology Innovation Commission of Shenzhen, China (KQTD2015032416270385, JCYJ20150625103619275, JCYJ20170818141407343, JCYJ20170818141519879, JCYJ20170818141429525 and JCYJ20170811093453105). China Postdoctoral Science Foundation, China (Grants 2017M620383; 2018M633118; 2018M633127). This work was also supported in part by a CRI project, South Korea (Grant No. 2018R1A3B1052702, J.S.K.) and a NRF, South Korea grant (Grant No. 2018R1A2A1A05020236, S.-G.C.) and Basic Science Research Program (Grant No. 2017R1D1A1B03030062, M.W.) from the National Research Foundation of Korea, South Korea.
Funding Information:
This research was supported in partially by the National Natural Science Fund , China (Grant No. 61875138 , 61435010 , 11904239 and 6181101252 ), and Science and Technology Innovation Commission of Shenzhen , China ( KQTD2015032416270385 , JCYJ20150625103619275 , JCYJ20170818141407343 , JCYJ20170818141519879 , JCYJ20170818141429525 and JCYJ20170811093453105 ). China Postdoctoral Science Foundation , China (Grants 2017M620383 ; 2018M633118 ; 2018M633127 ). This work was also supported in part by a CRI project, South Korea (Grant No. 2018R1A3B1052702 , J.S.K.) and a NRF , South Korea grant (Grant No. 2018R1A2A1A05020236 , S.-G.C.) and Basic Science Research Program (Grant No. 2017R1D1A1B03030062 , M.W.) from the National Research Foundation of Korea , South Korea.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - 2D materials (e.g., graphene, graphene analogues), with unique physical and chemical properties, shows intriguing potential for the realization of versatile biomedical applications. Tremendous attention has been attracted on 2D material based nanocarriers, which play a crucial role in therapeutic drug, gene, and biomedical agent delivery for cancer theranostics. This review provides an up-to-date review on the development of nanocarriers based on 2D materials beyond graphene, including basic and emerging synthesis methods, the catalog of 2D material-based nanocarriers, biosafety, surface functional engineering, the realization of stimuli-responsive controllable release and biomedical applications. Among the properties and performance to be summarized, there is particular focus on nanocarriers loading capability, biosafety, and therapy efficiency and so on. Finally, by addressing major issues and challenges, some prospects for future directions in this area are provided.
AB - 2D materials (e.g., graphene, graphene analogues), with unique physical and chemical properties, shows intriguing potential for the realization of versatile biomedical applications. Tremendous attention has been attracted on 2D material based nanocarriers, which play a crucial role in therapeutic drug, gene, and biomedical agent delivery for cancer theranostics. This review provides an up-to-date review on the development of nanocarriers based on 2D materials beyond graphene, including basic and emerging synthesis methods, the catalog of 2D material-based nanocarriers, biosafety, surface functional engineering, the realization of stimuli-responsive controllable release and biomedical applications. Among the properties and performance to be summarized, there is particular focus on nanocarriers loading capability, biosafety, and therapy efficiency and so on. Finally, by addressing major issues and challenges, some prospects for future directions in this area are provided.
KW - 2D material
KW - Cancer therapy
KW - Drug delivery
KW - Nanocarrier
KW - Nanomaterial
UR - http://www.scopus.com/inward/record.url?scp=85071949781&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2019.213041
DO - 10.1016/j.ccr.2019.213041
M3 - Review article
AN - SCOPUS:85071949781
VL - 400
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
SN - 0010-8545
M1 - 213041
ER -
