Emerging functions of circular RNA in aging

Eunah Kim; Yoon Ki Kim; Seung Jae V. Lee

doi:10.1016/j.tig.2021.04.014

Emerging functions of circular RNA in aging

Eunah Kim, Yoon Ki Kim, Seung Jae V. Lee

Department of Life Sciences

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes. Recent studies indicate that the levels of circRNAs change with age in various tissues in multiple species, ranging from nematodes to mammals. Here we discuss the functional roles of circRNAs in animal aging and longevity. We review studies regarding the differential expression of circRNAs that contributes to cellular senescence and the pathogenesis of aging-associated diseases. We explore the features of aging-associated circRNAs by discussing their potential as biomarkers of aging, tissue specificity, physiological roles, action mechanisms, and evolutionarily conserved characteristics. Our review provides insights into current progress in circRNA research and their significant functions in the aging process.

Original language	English
Pages (from-to)	819-829
Number of pages	11
Journal	Trends in Genetics
Volume	37
Issue number	9
DOIs	https://doi.org/10.1016/j.tig.2021.04.014
Publication status	Published - 2021 Sept

Keywords

age-associated disease
aging
biomarker of aging
circular RNAs
senescence

ASJC Scopus subject areas

Genetics

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10.1016/j.tig.2021.04.014

Cite this

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title = "Emerging functions of circular RNA in aging",

abstract = "Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes. Recent studies indicate that the levels of circRNAs change with age in various tissues in multiple species, ranging from nematodes to mammals. Here we discuss the functional roles of circRNAs in animal aging and longevity. We review studies regarding the differential expression of circRNAs that contributes to cellular senescence and the pathogenesis of aging-associated diseases. We explore the features of aging-associated circRNAs by discussing their potential as biomarkers of aging, tissue specificity, physiological roles, action mechanisms, and evolutionarily conserved characteristics. Our review provides insights into current progress in circRNA research and their significant functions in the aging process.",

keywords = "age-associated disease, aging, biomarker of aging, circular RNAs, senescence",

author = "Eunah Kim and Kim, {Yoon Ki} and Lee, {Seung Jae V.}",

note = "Funding Information: This study is supported by the Korean Government (MSICT) through the National Research Foundation of Korea (NRF) (NRF- 2019R1A3B2067745 to S-J.V.L. and NRF-2020R1C1C1013546 to E.K.). We thank all Lee laboratory members for valuable comments on the manuscript. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = sep,

doi = "10.1016/j.tig.2021.04.014",

language = "English",

volume = "37",

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journal = "Trends in Genetics",

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publisher = "Elsevier Limited",

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T1 - Emerging functions of circular RNA in aging

AU - Kim, Eunah

AU - Kim, Yoon Ki

AU - Lee, Seung Jae V.

N1 - Funding Information: This study is supported by the Korean Government (MSICT) through the National Research Foundation of Korea (NRF) (NRF- 2019R1A3B2067745 to S-J.V.L. and NRF-2020R1C1C1013546 to E.K.). We thank all Lee laboratory members for valuable comments on the manuscript. Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021/9

Y1 - 2021/9

N2 - Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes. Recent studies indicate that the levels of circRNAs change with age in various tissues in multiple species, ranging from nematodes to mammals. Here we discuss the functional roles of circRNAs in animal aging and longevity. We review studies regarding the differential expression of circRNAs that contributes to cellular senescence and the pathogenesis of aging-associated diseases. We explore the features of aging-associated circRNAs by discussing their potential as biomarkers of aging, tissue specificity, physiological roles, action mechanisms, and evolutionarily conserved characteristics. Our review provides insights into current progress in circRNA research and their significant functions in the aging process.

AB - Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes. Recent studies indicate that the levels of circRNAs change with age in various tissues in multiple species, ranging from nematodes to mammals. Here we discuss the functional roles of circRNAs in animal aging and longevity. We review studies regarding the differential expression of circRNAs that contributes to cellular senescence and the pathogenesis of aging-associated diseases. We explore the features of aging-associated circRNAs by discussing their potential as biomarkers of aging, tissue specificity, physiological roles, action mechanisms, and evolutionarily conserved characteristics. Our review provides insights into current progress in circRNA research and their significant functions in the aging process.

KW - age-associated disease

KW - aging

KW - biomarker of aging

KW - circular RNAs

KW - senescence

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U2 - 10.1016/j.tig.2021.04.014

DO - 10.1016/j.tig.2021.04.014

M3 - Review article

C2 - 34016449

AN - SCOPUS:85105877532

SN - 0168-9525

VL - 37

SP - 819

EP - 829

JO - Trends in Genetics

JF - Trends in Genetics

IS - 9

ER -

Emerging functions of circular RNA in aging

Abstract

Keywords

ASJC Scopus subject areas

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