Emerging potential of exosomes in regenerative medicine for temporomandibular joint osteoarthritis

Yeon Hee Lee, Hee Kyung Park, Q. Schick Auh, Haram Nah, Jae Seo Lee, Ho Jin Moon, Dong Nyoung Heo, In San Kim, Il Keun Kwon

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


Exosomes are nanosized vesicles (30–140 nm) of endocytic origin that play important roles in regenerative medicine. They are derived from cell membranes during endocytic internalization and stabilize in biological fluids such as blood and synovia. Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, which, in addition to chronic pain, is characterized by progressive cartilage breakdown, condylar bone remodeling, and synovitis. However, traditional clinical treatments have limited symptom‐ and structure‐modifying effects to restore damaged cartilage and other TMJ tissues. This is due to the limited self‐healing capacity of condylar cartilage. Recently, stem‐cell‐derived exosomes have been studied as an alternative therapeutic approach to tissue repair and regeneration. It is known that trophic regulation of mesenchymal stem cells (MSCs) has anti‐inflammatory and immunomodulatory effects under pathological conditions, and research on MSC‐derived exosomes is rapidly accumulating. MSC‐derived exosomes mimic the major therapeutic effects of MSCs. They affect the activity of immune effector cells and possess multilineage differentiation potential, including chondrogenic and osteogenic differentiation. Furthermore, exosomes are capable of regenerating cartilage or osseous compartments and restoring injured tissues and can treat dysfunction and pain caused by TMJ OA. In this review, we looked at the uniqueness of TMJ, the pathogenesis of TMJ OA, and the potential role of MSC‐derived exosomes for TMJ cartilage and bone regeneration.

Original languageEnglish
Article number1541
JournalInternational journal of molecular sciences
Issue number4
Publication statusPublished - 2020 Feb 2
Externally publishedYes


  • Exosome
  • Mesenchymal stem cell
  • Osteoarthritis
  • Osteochondral regeneration
  • Regenerative medicine
  • Temporomandibular joint

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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