Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger

Sangseong Kim, Sun Wook Hwang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Transient receptor potential ankyrin subtype 1 (TRPA1) is a well-known ion channel that play a central role for pain sensation. In the peripheral sensory nerve terminals innervating the body tegument or organs, TRPA1 detects and is activated by diverse harmful environmental and internal stimuli. The TRPA1 activation results in neuronal firing, which finally sends a warning signal to our brain. However, sensitization or sustained activation of TRPA1 often causes plastic changes both in the neural pathway and in the peripheral tissues, leading to a pathologic state in tissue health and pain mediation. Recently, a unique covalent detection mode for reactive biological attacks was uncovered in the sensory mechanisms of TRPA1. Notably, the pool of the newly found reactive stimulators for TRPA1 includes oxidative stress. Here, we overview the nature of this interaction, and try to find biological meanings of the participation of such a rapid ionotrophic component in disease exacerbations. Acutely, its relatively rapid response can be understood in terms of efficiency for avoiding harmful milieu as quickly as possible, as implicated in the raison d'etre of the pain mechanism. Nonetheless, complex situations in a chronic disease progress may occur. As well, multiple interplays with known molecules on the redox defense mechanism are anticipated. At a therapeutic angle, how to control TRPA1 for promoting body's defensive potential will be a practical question but remains to be answered. Future investigations will likely give more detailed insights to understand the roles and target validity of TRPA1.

Original languageEnglish
Pages (from-to)783-791
Number of pages9
JournalArchives of Pharmacal Research
Volume36
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Ankyrins
Oxidative stress
Oxidative Stress
Chemical activation
Tissue
Nociceptive Pain
Pain
Neural Pathways
Defense Mechanisms
Ion Channels
Peripheral Nerves
Oxidation-Reduction
Disease Progression
Brain
Chronic Disease
Health
Molecules

Keywords

  • Inflammation
  • Ion channel
  • Oxidative stress
  • Pain
  • Respiratory hypersensitivity
  • TRPA1

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Organic Chemistry

Cite this

Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger. / Kim, Sangseong; Hwang, Sun Wook.

In: Archives of Pharmacal Research, Vol. 36, No. 7, 01.07.2013, p. 783-791.

Research output: Contribution to journalArticle

@article{bde498ff57554e8b905e9c629e6c29bd,
title = "Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger",
abstract = "Transient receptor potential ankyrin subtype 1 (TRPA1) is a well-known ion channel that play a central role for pain sensation. In the peripheral sensory nerve terminals innervating the body tegument or organs, TRPA1 detects and is activated by diverse harmful environmental and internal stimuli. The TRPA1 activation results in neuronal firing, which finally sends a warning signal to our brain. However, sensitization or sustained activation of TRPA1 often causes plastic changes both in the neural pathway and in the peripheral tissues, leading to a pathologic state in tissue health and pain mediation. Recently, a unique covalent detection mode for reactive biological attacks was uncovered in the sensory mechanisms of TRPA1. Notably, the pool of the newly found reactive stimulators for TRPA1 includes oxidative stress. Here, we overview the nature of this interaction, and try to find biological meanings of the participation of such a rapid ionotrophic component in disease exacerbations. Acutely, its relatively rapid response can be understood in terms of efficiency for avoiding harmful milieu as quickly as possible, as implicated in the raison d'etre of the pain mechanism. Nonetheless, complex situations in a chronic disease progress may occur. As well, multiple interplays with known molecules on the redox defense mechanism are anticipated. At a therapeutic angle, how to control TRPA1 for promoting body's defensive potential will be a practical question but remains to be answered. Future investigations will likely give more detailed insights to understand the roles and target validity of TRPA1.",
keywords = "Inflammation, Ion channel, Oxidative stress, Pain, Respiratory hypersensitivity, TRPA1",
author = "Sangseong Kim and Hwang, {Sun Wook}",
year = "2013",
month = "7",
day = "1",
doi = "10.1007/s12272-013-0098-2",
language = "English",
volume = "36",
pages = "783--791",
journal = "Archives of Pharmacal Research",
issn = "0253-6269",
publisher = "Pharmaceutical Society of Korea",
number = "7",

}

TY - JOUR

T1 - Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger

AU - Kim, Sangseong

AU - Hwang, Sun Wook

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Transient receptor potential ankyrin subtype 1 (TRPA1) is a well-known ion channel that play a central role for pain sensation. In the peripheral sensory nerve terminals innervating the body tegument or organs, TRPA1 detects and is activated by diverse harmful environmental and internal stimuli. The TRPA1 activation results in neuronal firing, which finally sends a warning signal to our brain. However, sensitization or sustained activation of TRPA1 often causes plastic changes both in the neural pathway and in the peripheral tissues, leading to a pathologic state in tissue health and pain mediation. Recently, a unique covalent detection mode for reactive biological attacks was uncovered in the sensory mechanisms of TRPA1. Notably, the pool of the newly found reactive stimulators for TRPA1 includes oxidative stress. Here, we overview the nature of this interaction, and try to find biological meanings of the participation of such a rapid ionotrophic component in disease exacerbations. Acutely, its relatively rapid response can be understood in terms of efficiency for avoiding harmful milieu as quickly as possible, as implicated in the raison d'etre of the pain mechanism. Nonetheless, complex situations in a chronic disease progress may occur. As well, multiple interplays with known molecules on the redox defense mechanism are anticipated. At a therapeutic angle, how to control TRPA1 for promoting body's defensive potential will be a practical question but remains to be answered. Future investigations will likely give more detailed insights to understand the roles and target validity of TRPA1.

AB - Transient receptor potential ankyrin subtype 1 (TRPA1) is a well-known ion channel that play a central role for pain sensation. In the peripheral sensory nerve terminals innervating the body tegument or organs, TRPA1 detects and is activated by diverse harmful environmental and internal stimuli. The TRPA1 activation results in neuronal firing, which finally sends a warning signal to our brain. However, sensitization or sustained activation of TRPA1 often causes plastic changes both in the neural pathway and in the peripheral tissues, leading to a pathologic state in tissue health and pain mediation. Recently, a unique covalent detection mode for reactive biological attacks was uncovered in the sensory mechanisms of TRPA1. Notably, the pool of the newly found reactive stimulators for TRPA1 includes oxidative stress. Here, we overview the nature of this interaction, and try to find biological meanings of the participation of such a rapid ionotrophic component in disease exacerbations. Acutely, its relatively rapid response can be understood in terms of efficiency for avoiding harmful milieu as quickly as possible, as implicated in the raison d'etre of the pain mechanism. Nonetheless, complex situations in a chronic disease progress may occur. As well, multiple interplays with known molecules on the redox defense mechanism are anticipated. At a therapeutic angle, how to control TRPA1 for promoting body's defensive potential will be a practical question but remains to be answered. Future investigations will likely give more detailed insights to understand the roles and target validity of TRPA1.

KW - Inflammation

KW - Ion channel

KW - Oxidative stress

KW - Pain

KW - Respiratory hypersensitivity

KW - TRPA1

UR - http://www.scopus.com/inward/record.url?scp=84880043207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880043207&partnerID=8YFLogxK

U2 - 10.1007/s12272-013-0098-2

DO - 10.1007/s12272-013-0098-2

M3 - Article

VL - 36

SP - 783

EP - 791

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

SN - 0253-6269

IS - 7

ER -