Emerging roles of TWIK-1 heterodimerization in the brain

Chang Hoon Cho, Eun Mi Hwang, Jae Yong Park

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Two-pore domain K+ (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK—tandem of pore domains in a weak inward rectifying K+ channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain.

Original languageEnglish
Article number51
JournalInternational journal of molecular sciences
Issue number1
Publication statusPublished - 2018 Jan


  • Astrocyte
  • Brain
  • Heterodimerization
  • K2P
  • TWIK-1

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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