Emerging roles of TWIK-1 heterodimerization in the brain

Chang Hoon Cho, Eun Mi Hwang, Jae-Yong Park

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Two-pore domain K + (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK—tandem of pore domains in a weak inward rectifying K + channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain.

Original languageEnglish
Article number51
JournalInternational journal of molecular sciences
Volume19
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Membrane Potentials
brain
Glutamic Acid
emerging
Brain
Neurons
porosity
glutamates
Membranes
neurons
membranes

Keywords

  • Astrocyte
  • Brain
  • Heterodimerization
  • K2P
  • TWIK-1

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Emerging roles of TWIK-1 heterodimerization in the brain. / Cho, Chang Hoon; Hwang, Eun Mi; Park, Jae-Yong.

In: International journal of molecular sciences, Vol. 19, No. 1, 51, 01.01.2018.

Research output: Contribution to journalReview article

@article{19a5c70ce10045f2ac72deb4feb22ac9,
title = "Emerging roles of TWIK-1 heterodimerization in the brain",
abstract = "Two-pore domain K + (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK—tandem of pore domains in a weak inward rectifying K + channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain.",
keywords = "Astrocyte, Brain, Heterodimerization, K2P, TWIK-1",
author = "Cho, {Chang Hoon} and Hwang, {Eun Mi} and Jae-Yong Park",
year = "2018",
month = "1",
day = "1",
doi = "10.3390/ijms19010051",
language = "English",
volume = "19",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

TY - JOUR

T1 - Emerging roles of TWIK-1 heterodimerization in the brain

AU - Cho, Chang Hoon

AU - Hwang, Eun Mi

AU - Park, Jae-Yong

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Two-pore domain K + (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK—tandem of pore domains in a weak inward rectifying K + channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain.

AB - Two-pore domain K + (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK—tandem of pore domains in a weak inward rectifying K + channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain.

KW - Astrocyte

KW - Brain

KW - Heterodimerization

KW - K2P

KW - TWIK-1

UR - http://www.scopus.com/inward/record.url?scp=85039067290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039067290&partnerID=8YFLogxK

U2 - 10.3390/ijms19010051

DO - 10.3390/ijms19010051

M3 - Review article

C2 - 29295556

AN - SCOPUS:85039067290

VL - 19

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 1

M1 - 51

ER -