TY - JOUR
T1 - Enabling techniques in the search for new antibiotics
T2 - Combinatorial biosynthesis of sugar-containing antibiotics
AU - Park, Je Won
AU - Nam, Sang Jip
AU - Yoon, Yeo Joon
N1 - Funding Information:
We thank Dr. Kris Rathwell for critical reading this manuscript. This work was supported by the National Research Foundation of Korea grant (2016R1A2A1A05005078, 2015R1A2A2A01002524 [J.W.P.]) funded by the Ministry of Science, ICT and Future Planning (MISP), the Intelligent Synthetic Biology Center of the Global Frontier Project funded by MISP (20110031961), Advanced Production Technology Development Program and High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea. J.W.P. also thanks to the grant (PJ011066) funded by the Next-Generation BioGreen21 program, Rural Development Administration.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2017/6/15
Y1 - 2017/6/15
N2 - Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era.
AB - Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era.
KW - Anti-infective and anti-proliferative
KW - Combinatorial biosynthesis
KW - Sugar-containing antibiotics
UR - http://www.scopus.com/inward/record.url?scp=85005784386&partnerID=8YFLogxK
U2 - 10.1016/j.bcp.2016.10.009
DO - 10.1016/j.bcp.2016.10.009
M3 - Review article
C2 - 27793719
AN - SCOPUS:85005784386
VL - 134
SP - 56
EP - 73
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
ER -