Abstract
Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era.
| Original language | English |
|---|---|
| Pages (from-to) | 56-73 |
| Number of pages | 18 |
| Journal | Biochemical Pharmacology |
| Volume | 134 |
| DOIs | |
| Publication status | Published - 2017 Jun 15 |
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Keywords
- Anti-infective and anti-proliferative
- Combinatorial biosynthesis
- Sugar-containing antibiotics
ASJC Scopus subject areas
- Biochemistry
- Pharmacology
Cite this
Enabling techniques in the search for new antibiotics : Combinatorial biosynthesis of sugar-containing antibiotics. / Park, Je Won; Nam, Sang Jip; Yoon, Yeo Joon.
In: Biochemical Pharmacology, Vol. 134, 15.06.2017, p. 56-73.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Enabling techniques in the search for new antibiotics
T2 - Combinatorial biosynthesis of sugar-containing antibiotics
AU - Park, Je Won
AU - Nam, Sang Jip
AU - Yoon, Yeo Joon
PY - 2017/6/15
Y1 - 2017/6/15
N2 - Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era.
AB - Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010–2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era.
KW - Anti-infective and anti-proliferative
KW - Combinatorial biosynthesis
KW - Sugar-containing antibiotics
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UR - http://www.scopus.com/inward/citedby.url?scp=85005784386&partnerID=8YFLogxK
U2 - 10.1016/j.bcp.2016.10.009
DO - 10.1016/j.bcp.2016.10.009
M3 - Review article
C2 - 27793719
AN - SCOPUS:85005784386
VL - 134
SP - 56
EP - 73
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
ER -