Enantioselective additions of diethylzinc and diphenylzinc to aldehydes using 2-dialkyl-aminomethyl-2′-hydroxy-1,1′-binaphthyls

Dong Hyun Ko, Kyoung Hoon Kim, Deok-Chan Ha

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Abstract

(graph presented) A set of 2-dialkylaminomethyl-2′-hydroxy-1,1′-binaphthyls was prepared and used in the catalytic asymmetric additions of diethylzinc and diphenylzinc to various types of aldehydes. These binaphthyl-based axially chiral amino alcohols show high enantioselectivity in the addition of organozincs to aromatic and aliphatic aldehydes.

Original languageEnglish
Pages (from-to)3759-3762
Number of pages4
JournalOrganic Letters
Volume4
Issue number21
DOIs
Publication statusPublished - 2002 Oct 17

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ASJC Scopus subject areas

  • Molecular Medicine

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