Enantioselective additions of diethylzinc and diphenylzinc to aldehydes using 2-dialkyl-aminomethyl-2′-hydroxy-1,1′-binaphthyls

Dong Hyun Ko; Kyoung Hoon Kim; Deok Chan Ha

doi:10.1021/ol026761j

Enantioselective additions of diethylzinc and diphenylzinc to aldehydes using 2-dialkyl-aminomethyl-2′-hydroxy-1,1′-binaphthyls

Dong Hyun Ko, Kyoung Hoon Kim, Deok Chan Ha

College of Science

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Abstract

(graph presented) A set of 2-dialkylaminomethyl-2′-hydroxy-1,1′-binaphthyls was prepared and used in the catalytic asymmetric additions of diethylzinc and diphenylzinc to various types of aldehydes. These binaphthyl-based axially chiral amino alcohols show high enantioselectivity in the addition of organozincs to aromatic and aliphatic aldehydes.

Original language	English
Pages (from-to)	3759-3762
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	21
DOIs	https://doi.org/10.1021/ol026761j
Publication status	Published - 2002 Oct 17

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol026761j

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abstract = "(graph presented) A set of 2-dialkylaminomethyl-2′-hydroxy-1,1′-binaphthyls was prepared and used in the catalytic asymmetric additions of diethylzinc and diphenylzinc to various types of aldehydes. These binaphthyl-based axially chiral amino alcohols show high enantioselectivity in the addition of organozincs to aromatic and aliphatic aldehydes.",

author = "Ko, {Dong Hyun} and Kim, {Kyoung Hoon} and Ha, {Deok Chan}",

year = "2002",

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AU - Ko, Dong Hyun

AU - Kim, Kyoung Hoon

AU - Ha, Deok Chan

PY - 2002/10/17

Y1 - 2002/10/17

N2 - (graph presented) A set of 2-dialkylaminomethyl-2′-hydroxy-1,1′-binaphthyls was prepared and used in the catalytic asymmetric additions of diethylzinc and diphenylzinc to various types of aldehydes. These binaphthyl-based axially chiral amino alcohols show high enantioselectivity in the addition of organozincs to aromatic and aliphatic aldehydes.

AB - (graph presented) A set of 2-dialkylaminomethyl-2′-hydroxy-1,1′-binaphthyls was prepared and used in the catalytic asymmetric additions of diethylzinc and diphenylzinc to various types of aldehydes. These binaphthyl-based axially chiral amino alcohols show high enantioselectivity in the addition of organozincs to aromatic and aliphatic aldehydes.

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Enantioselective additions of diethylzinc and diphenylzinc to aldehydes using 2-dialkyl-aminomethyl-2′-hydroxy-1,1′-binaphthyls

Abstract

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