Abstract
A new protocol for the synthesis of chiral β-aminotetralins has been developed via chiral phosphoric acid-catalyzed asymmetric reductive amination of β-tetralones using a Hantzsch ester as an organic hydride donor. Various chiral β-aminotetralins were obtained in good yields with good to high enantioselectivities. Furthermore, the utility of our new protocol was successfully demonstrated in the enantioselective synthesis of rotigotine.
Original language | English |
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Journal | Advanced Synthesis and Catalysis |
DOIs | |
Publication status | Accepted/In press - 2017 Jan 1 |
Keywords
- Asymmetric reductive amination
- Chiral phosphoric acid catalysis
- Rotigotine
- β-Aminotetralins
- β-Tetralones
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry