Abstract
A new protocol for the synthesis of chiral β-aminotetralins has been developed via chiral phosphoric acid-catalyzed asymmetric reductive amination of β-tetralones using a Hantzsch ester as an organic hydride donor. Various chiral β-aminotetralins were obtained in good yields with good to high enantioselectivities. Furthermore, the utility of our new protocol was successfully demonstrated in the enantioselective synthesis of rotigotine. (Figure presented.).
Original language | English |
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Pages (from-to) | 462-467 |
Number of pages | 6 |
Journal | Advanced Synthesis and Catalysis |
Volume | 360 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2018 Feb 1 |
Keywords
- Asymmetric reductive amination
- Chiral phosphoric acid catalysis
- Rotigotine
- β-Aminotetralins
- β-Tetralones
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry