Encapsulation of vitamin C in tripolyphosphate cross-linked chitosan microspheres by spray drying

K. G H Desai, Hyun Jin Park

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

This paper describes vitamin C-encapsulated chitosan microspheres cross-linked with tripolyphosphate (TPP) using a new process prepared by spray drying intended for oral delivery of vitamin C. Thus, prepared microspheres were evaluated by loading efficiency, particles size analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), zeta potential and in vitro release studies. The microspheres so prepared had a good sphericity and shape but varied with the volume of cross-linking agent solution added. Tley were positively charged. The mean particle size ranged from 6.1-9.0 μm. The size, shape, encapsulation efficiency, zeta potential and release rate were influenced by the volume of cross-linking agent. With the increasing amount of cross-linking agent, both the particle size and release rate were increased. Encapsulation efficiency decreased from 45.05-58.30% with the increasing amount of TPP solution from 10-30 ml. FTIR spectroscopy study showed that the vitamin C was found to be stable after encapsulation. XRD studies revealed that vitamin C is dispersed at the molecular level in the TPP-chitosan matrix. Well-defined change in the surface morphology was observed with the varying volume of TPP. The sphericity of chitosan microspheres was lost at higher volume of cross-linking agent. The release of vitamin C from these microspheres was sustained and affected by the volume of cross-linking agent added. The release of vitamin C from TPP-chitosan microspheres followed Fick's law of diffusion.

Original languageEnglish
Pages (from-to)179-192
Number of pages14
JournalJournal of Microencapsulation
Volume22
Issue number2
DOIs
Publication statusPublished - 2005 Mar 1

Keywords

  • Chitosan
  • Controlled release
  • Cross-linked microspheres
  • Microspheres
  • Spray drying
  • TPP
  • Vitamin C

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Pharmaceutical Science
  • Chemical Engineering(all)
  • Pharmacology

Fingerprint Dive into the research topics of 'Encapsulation of vitamin C in tripolyphosphate cross-linked chitosan microspheres by spray drying'. Together they form a unique fingerprint.

  • Cite this