Encapsulation of vitamin C in tripolyphosphate cross-linked chitosan microspheres by spray drying

K. G H Desai, Hyun Jin Park

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

This paper describes vitamin C-encapsulated chitosan microspheres cross-linked with tripolyphosphate (TPP) using a new process prepared by spray drying intended for oral delivery of vitamin C. Thus, prepared microspheres were evaluated by loading efficiency, particles size analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), zeta potential and in vitro release studies. The microspheres so prepared had a good sphericity and shape but varied with the volume of cross-linking agent solution added. Tley were positively charged. The mean particle size ranged from 6.1-9.0 μm. The size, shape, encapsulation efficiency, zeta potential and release rate were influenced by the volume of cross-linking agent. With the increasing amount of cross-linking agent, both the particle size and release rate were increased. Encapsulation efficiency decreased from 45.05-58.30% with the increasing amount of TPP solution from 10-30 ml. FTIR spectroscopy study showed that the vitamin C was found to be stable after encapsulation. XRD studies revealed that vitamin C is dispersed at the molecular level in the TPP-chitosan matrix. Well-defined change in the surface morphology was observed with the varying volume of TPP. The sphericity of chitosan microspheres was lost at higher volume of cross-linking agent. The release of vitamin C from these microspheres was sustained and affected by the volume of cross-linking agent added. The release of vitamin C from TPP-chitosan microspheres followed Fick's law of diffusion.

Original languageEnglish
Pages (from-to)179-192
Number of pages14
JournalJournal of Microencapsulation
Volume22
Issue number2
DOIs
Publication statusPublished - 2005 Mar 1

Fingerprint

Spray drying
ascorbic acid
Vitamins
Chitosan
Microspheres
Encapsulation
drying
Ascorbic Acid
sprayers
Particle Size
Fourier Transform Infrared Spectroscopy
Zeta potential
X-Ray Diffraction
Fourier transform infrared spectroscopy
infrared spectroscopy
Particle size
Fick's laws
X ray diffraction
Transmission Electron Microscopy
diffraction

Keywords

  • Chitosan
  • Controlled release
  • Cross-linked microspheres
  • Microspheres
  • Spray drying
  • TPP
  • Vitamin C

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Pharmaceutical Science
  • Chemical Engineering(all)
  • Pharmacology

Cite this

Encapsulation of vitamin C in tripolyphosphate cross-linked chitosan microspheres by spray drying. / Desai, K. G H; Park, Hyun Jin.

In: Journal of Microencapsulation, Vol. 22, No. 2, 01.03.2005, p. 179-192.

Research output: Contribution to journalArticle

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