Endometrial mullerian adenosarcoma after toremifene treatment in breast cancer patients: A case report

Ye Won Chung, Hyo Sook Bae, Song I. Han, Jae Yun Song, In Sun Kim, Seong Jae Kang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Toremifene is an anti-estrogen which has been shown to be effective in the treatment of breast cancer, and is thought to be a less uterotrophic agent than tamoxifen. The risk assessment concerning endometrial cancer has been inconclusive because of its rare use up to the mid-1990s. We report a case of an adenosarcoma, which is a very rare type of uterine malignancy, after toremifene treatment for 5 years in a breast cancer patient. After 1 year of toremifene use, the patient had a benign Mullerian adenofibroma. After an additional 4 years of toremifene treatment, the endometrial polypoid lesion was transformed into a Mullerian adenosarcoma. Although toremifene is a promising anti-estrogenic agent in the treatment of breast cancer patients, clinicians should not neglect the possibility of a uterine malignancy.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalJournal of Gynecologic Oncology
Volume21
Issue number4
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Adenosarcoma
Toremifene
Breast Neoplasms
Estrogens
Adenofibroma
Therapeutics
Tamoxifen
Endometrial Neoplasms
Neoplasms

Keywords

  • Breast cancer
  • Mullerian adenofibroma
  • Mullerian adenosarcoma
  • Tamoxifen
  • Toremifene

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Endometrial mullerian adenosarcoma after toremifene treatment in breast cancer patients : A case report. / Chung, Ye Won; Bae, Hyo Sook; Han, Song I.; Song, Jae Yun; Kim, In Sun; Kang, Seong Jae.

In: Journal of Gynecologic Oncology, Vol. 21, No. 4, 01.12.2010, p. 269-272.

Research output: Contribution to journalArticle

Chung, Ye Won ; Bae, Hyo Sook ; Han, Song I. ; Song, Jae Yun ; Kim, In Sun ; Kang, Seong Jae. / Endometrial mullerian adenosarcoma after toremifene treatment in breast cancer patients : A case report. In: Journal of Gynecologic Oncology. 2010 ; Vol. 21, No. 4. pp. 269-272.
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