Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis

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5 Citations (Scopus)

Abstract

Background: The cervical lymph node metastasis (CLNM) of papillary thyroid microcarcinoma (PTMC) is not uncommon. However, prophylactic cervical lymph node dissection in all PTMC is debatable. Molecular markers of predicting CLNM would help to decide to either do or not do cervical lymph node dissection which might increase morbidities. Aims: We aimed to characterize gene expression profiles and molecular markers of CLNM in PTMC. Settings and Design: The thyroid frozen tissues were obtained with from six PTMC patients, who underwent total thyroidectomy. Methods: We performed oligonucleotide microarray analysis with three PTMCs with CLNM and three without CLNM. Real-time quantitative reverse transcription-polymerase chain reaction was used to validate the gene. Statistical Analysis Used: We used linear models for microarray data. Results: We identified 12 differentially expressed gene, and most one is endoplasmic reticulum aminopeptidase 2 (ERAP2). Conclusion: ERAP2 might be associated with CLNM in PTMC.

Original languageEnglish
Pages (from-to)443-446
Number of pages4
JournalJournal of Cancer Research and Therapeutics
Volume11
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

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Aminopeptidases
Endoplasmic Reticulum
Lymph Nodes
Neoplasm Metastasis
Lymph Node Excision
Thyroidectomy
Microarray Analysis
Oligonucleotide Array Sequence Analysis
Transcriptome
Genes
Reverse Transcription
Papillary Thyroid Microcarcinoma
Linear Models
Thyroid Gland
Morbidity
Polymerase Chain Reaction

Keywords

  • Lymph nodes
  • metastasis
  • microarray analysis
  • thyroid neoplasm

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis",
abstract = "Background: The cervical lymph node metastasis (CLNM) of papillary thyroid microcarcinoma (PTMC) is not uncommon. However, prophylactic cervical lymph node dissection in all PTMC is debatable. Molecular markers of predicting CLNM would help to decide to either do or not do cervical lymph node dissection which might increase morbidities. Aims: We aimed to characterize gene expression profiles and molecular markers of CLNM in PTMC. Settings and Design: The thyroid frozen tissues were obtained with from six PTMC patients, who underwent total thyroidectomy. Methods: We performed oligonucleotide microarray analysis with three PTMCs with CLNM and three without CLNM. Real-time quantitative reverse transcription-polymerase chain reaction was used to validate the gene. Statistical Analysis Used: We used linear models for microarray data. Results: We identified 12 differentially expressed gene, and most one is endoplasmic reticulum aminopeptidase 2 (ERAP2). Conclusion: ERAP2 might be associated with CLNM in PTMC.",
keywords = "Lymph nodes, metastasis, microarray analysis, thyroid neoplasm",
author = "Kim, {Woo Young} and Lee, {Jae Bok} and Kim, {Hoon Yub} and Woo, {Sang- Uk} and Son, {Gil Soo} and Jeoung Bae",
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T1 - Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis

AU - Kim, Woo Young

AU - Lee, Jae Bok

AU - Kim, Hoon Yub

AU - Woo, Sang- Uk

AU - Son, Gil Soo

AU - Bae, Jeoung

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: The cervical lymph node metastasis (CLNM) of papillary thyroid microcarcinoma (PTMC) is not uncommon. However, prophylactic cervical lymph node dissection in all PTMC is debatable. Molecular markers of predicting CLNM would help to decide to either do or not do cervical lymph node dissection which might increase morbidities. Aims: We aimed to characterize gene expression profiles and molecular markers of CLNM in PTMC. Settings and Design: The thyroid frozen tissues were obtained with from six PTMC patients, who underwent total thyroidectomy. Methods: We performed oligonucleotide microarray analysis with three PTMCs with CLNM and three without CLNM. Real-time quantitative reverse transcription-polymerase chain reaction was used to validate the gene. Statistical Analysis Used: We used linear models for microarray data. Results: We identified 12 differentially expressed gene, and most one is endoplasmic reticulum aminopeptidase 2 (ERAP2). Conclusion: ERAP2 might be associated with CLNM in PTMC.

AB - Background: The cervical lymph node metastasis (CLNM) of papillary thyroid microcarcinoma (PTMC) is not uncommon. However, prophylactic cervical lymph node dissection in all PTMC is debatable. Molecular markers of predicting CLNM would help to decide to either do or not do cervical lymph node dissection which might increase morbidities. Aims: We aimed to characterize gene expression profiles and molecular markers of CLNM in PTMC. Settings and Design: The thyroid frozen tissues were obtained with from six PTMC patients, who underwent total thyroidectomy. Methods: We performed oligonucleotide microarray analysis with three PTMCs with CLNM and three without CLNM. Real-time quantitative reverse transcription-polymerase chain reaction was used to validate the gene. Statistical Analysis Used: We used linear models for microarray data. Results: We identified 12 differentially expressed gene, and most one is endoplasmic reticulum aminopeptidase 2 (ERAP2). Conclusion: ERAP2 might be associated with CLNM in PTMC.

KW - Lymph nodes

KW - metastasis

KW - microarray analysis

KW - thyroid neoplasm

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