Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

Ok Hyun Park, Hongseok Ha, Yujin Lee, Sung Ho Boo, Do Hoon Kwon, Hyun Kyu Song, Yoon Ki Kim

Research output: Contribution to journalArticlepeer-review

252 Citations (Scopus)


m6A-containing RNAs are known to be recognized and destabilized by YTHDF2. However, the underlying molecular mechanisms remain unclear. Park et al. show that m6A-containing linear and circular RNAs are endoribonucleolytically cleaved by a YTHDF2-HRSP12-RNase P/MRP axis.

Original languageEnglish
Pages (from-to)494-507.e8
JournalMolecular Cell
Issue number3
Publication statusPublished - 2019 May 2


  • CCR4-NOT complex
  • FTO
  • HRSP12
  • METTL3
  • RNA decay
  • RNase P/MRP
  • YTHDF2
  • circular RNA
  • endoribonucleolytic cleavage
  • mA modification

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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