Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter

Junyoung Kim, Jingchao Xing, Hyeong Soo Nam, Joon Woo Song, Jin Won Kim, Hongki Yoo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Micro-optical coherence tomography (μOCT) is an advanced imaging technique that acquires a three-dimensional microstructure of biological samples with a high spatial resolution, up to 1 μm, by using a broadband light source and a high numerical aperture (NA) lens. As high NA produces a short depth of focus (DOF), extending the DOF is necessary to obtain a reasonable imaging depth. However, due to the complexity of optics and the limited space, it has been challenging to fabricate endoscopic μOCT, which is essential for clinical translation. Here, we report an endoscopic μOCT probe with an extended DOF by using a binary phase spatial filter. The imaging results from latex beads demonstrated that the μOCT probe achieved an axial resolution of 2.49 μm and a lateral resolution of 2.59 μm with a DOF extended by a factor of 2. The feasibility of clinical use was demonstrated by ex vivo imaging of the rabbit iliac artery.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalOptics Letters
Volume42
Issue number3
DOIs
Publication statusPublished - 2017 Feb 1

Fingerprint

Optical Coherence Tomography
tomography
filters
numerical aperture
Iliac Artery
Microspheres
probes
Lenses
rabbits
arteries
latex
imaging techniques
beads
Rabbits
light sources
Light
spatial resolution
lenses
optics
broadband

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter. / Kim, Junyoung; Xing, Jingchao; Nam, Hyeong Soo; Song, Joon Woo; Kim, Jin Won; Yoo, Hongki.

In: Optics Letters, Vol. 42, No. 3, 01.02.2017, p. 379-382.

Research output: Contribution to journalArticle

Kim, Junyoung ; Xing, Jingchao ; Nam, Hyeong Soo ; Song, Joon Woo ; Kim, Jin Won ; Yoo, Hongki. / Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter. In: Optics Letters. 2017 ; Vol. 42, No. 3. pp. 379-382.
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