Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter

Junyoung Kim, Jingchao Xing, Hyeong Soo Nam, Joon Woo Song, Jin Won Kim, Hongki Yoo

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)

    Abstract

    Micro-optical coherence tomography (μOCT) is an advanced imaging technique that acquires a three-dimensional microstructure of biological samples with a high spatial resolution, up to 1 μm, by using a broadband light source and a high numerical aperture (NA) lens. As high NA produces a short depth of focus (DOF), extending the DOF is necessary to obtain a reasonable imaging depth. However, due to the complexity of optics and the limited space, it has been challenging to fabricate endoscopic μOCT, which is essential for clinical translation. Here, we report an endoscopic μOCT probe with an extended DOF by using a binary phase spatial filter. The imaging results from latex beads demonstrated that the μOCT probe achieved an axial resolution of 2.49 μm and a lateral resolution of 2.59 μm with a DOF extended by a factor of 2. The feasibility of clinical use was demonstrated by ex vivo imaging of the rabbit iliac artery.

    Original languageEnglish
    Pages (from-to)379-382
    Number of pages4
    JournalOptics Letters
    Volume42
    Issue number3
    DOIs
    Publication statusPublished - 2017 Feb 1

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics

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