Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway

Moon Ho Park, Hie Lee Dae

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron x neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.

Original languageEnglish
Pages (from-to)92-97
Number of pages6
JournalExperimental and Molecular Medicine
Volume40
Issue number1
DOIs
Publication statusPublished - 2008 Feb 29

Fingerprint

MAP Kinase Signaling System
Endothelin-1
Endothelins
Apoptosis
Serum
Endothelin-2
Endothelin-3
Calcium
Neurology
Neuroprotective Agents
Cell membranes
Programmable logic controllers
Neuroblastoma
Nervous System
Neurons
Transmitters
Chemical activation
Cell Membrane

Keywords

  • Calcium
  • Cell survival
  • Endothelins
  • Mitogen-activated protein kinase 1
  • Neurons
  • Protein kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway. / Park, Moon Ho; Dae, Hie Lee.

In: Experimental and Molecular Medicine, Vol. 40, No. 1, 29.02.2008, p. 92-97.

Research output: Contribution to journalArticle

@article{ee4674fa0388405ca019862cfa88a334,
title = "Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway",
abstract = "Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron x neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.",
keywords = "Calcium, Cell survival, Endothelins, Mitogen-activated protein kinase 1, Neurons, Protein kinase C",
author = "Park, {Moon Ho} and Dae, {Hie Lee}",
year = "2008",
month = "2",
day = "29",
doi = "10.3858/emm.2008.40.1.92",
language = "English",
volume = "40",
pages = "92--97",
journal = "Experimental and Molecular Medicine",
issn = "1226-3613",
publisher = "Korean Society of Med. Biochemistry and Mol. Biology",
number = "1",

}

TY - JOUR

T1 - Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway

AU - Park, Moon Ho

AU - Dae, Hie Lee

PY - 2008/2/29

Y1 - 2008/2/29

N2 - Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron x neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.

AB - Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron x neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.

KW - Calcium

KW - Cell survival

KW - Endothelins

KW - Mitogen-activated protein kinase 1

KW - Neurons

KW - Protein kinase C

UR - http://www.scopus.com/inward/record.url?scp=40449120485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40449120485&partnerID=8YFLogxK

U2 - 10.3858/emm.2008.40.1.92

DO - 10.3858/emm.2008.40.1.92

M3 - Article

C2 - 18305402

AN - SCOPUS:40449120485

VL - 40

SP - 92

EP - 97

JO - Experimental and Molecular Medicine

JF - Experimental and Molecular Medicine

SN - 1226-3613

IS - 1

ER -