Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway

Ho Park Moon; Hie Lee Dae

doi:10.3858/emm.2008.40.1.92

Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca²⁺-PKCα-ERK pathway

Ho Park Moon, Hie Lee Dae

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron x neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.

Original language	English
Pages (from-to)	92-97
Number of pages	6
Journal	Experimental and Molecular Medicine
Volume	40
Issue number	1
DOIs	https://doi.org/10.3858/emm.2008.40.1.92
Publication status	Published - 2008 Feb 29
Externally published	Yes

Keywords

Calcium
Cell survival
Endothelins
Mitogen-activated protein kinase 1
Neurons
Protein kinase C

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

Access to Document

10.3858/emm.2008.40.1.92

Cite this

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title = "Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway",

abstract = "Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron x neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.",

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AU - Dae, Hie Lee

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