Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway

Ho Park Moon, Hie Lee Dae

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron x neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.

    Original languageEnglish
    Pages (from-to)92-97
    Number of pages6
    JournalExperimental and Molecular Medicine
    Volume40
    Issue number1
    DOIs
    Publication statusPublished - 2008 Feb 29

    Keywords

    • Calcium
    • Cell survival
    • Endothelins
    • Mitogen-activated protein kinase 1
    • Neurons
    • Protein kinase C

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Clinical Biochemistry

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