Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway

Moon Ho Park, Hie Lee Dae

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4 Citations (Scopus)


Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron x neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.

Original languageEnglish
Pages (from-to)92-97
Number of pages6
JournalExperimental and Molecular Medicine
Issue number1
Publication statusPublished - 2008 Feb 29



  • Calcium
  • Cell survival
  • Endothelins
  • Mitogen-activated protein kinase 1
  • Neurons
  • Protein kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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