Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway

Moon Ho Park, Hie Lee Dae

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron x neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.

Original languageEnglish
Pages (from-to)92-97
Number of pages6
JournalExperimental and Molecular Medicine
Volume40
Issue number1
DOIs
Publication statusPublished - 2008 Feb 29

    Fingerprint

Keywords

  • Calcium
  • Cell survival
  • Endothelins
  • Mitogen-activated protein kinase 1
  • Neurons
  • Protein kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this