Engineering hydrogel ECM scaffold component for in vitro 3D skeletal muscle tissue

Jinchul Ahn, Hyoeun Jeong, Jaehoon Kim, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Skeletal muscle is contractile tissue and it is consisted of multiple bundles of myofibers (cells), which are long and multinucleated contractile cells. Each muscles and the myofibers are connected with various extracellular matrix (ECM) molecules. To investigate the adequate ECM components for muscle tissue generation, we designed 3D in vitro model with myogenic progenitor cells (myoblasts) and 7 case of hydrogel ECM compositions. The degree of tissue formation and the differentiation of cells were different in each hydrogel ECM cases. In the mixtures of collagen type I and Matrigel, the differentiation and the formation of muscle tissue were more induced.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1147-1148
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020 Jan 1
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 2017 Oct 222017 Oct 26

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period17/10/2217/10/26

Keywords

  • Alignment
  • Collagen
  • ECM
  • Hydrogel
  • Matrigel
  • Myogenesis

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Ahn, J., Jeong, H., Kim, J., & Chung, S. (2020). Engineering hydrogel ECM scaffold component for in vitro 3D skeletal muscle tissue. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1147-1148). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.