Engineering nanoparticle strategies for effective cancer immunotherapy

Hong Yeol Yoon, Subramanian Tamil Selvan, Yoosoo Yang, Min Ju Kim, Dong Kee Yi, Ick Chan Kwon, Kwang Meyung Kim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Cancer immunotherapy has been emerging in recent years, due to the inherent nature of the immune system. Although recent successes of immunotherapeutics in clinical application have attracted development of a novel immunotherapeutics, the off-target side effect and low immunogenicity of them remain challenges for the effective cancer immunotherapy. Theranostic nanoparticle system may one of key technology to address these issues by offering targeted delivery of various types of immunotherapeutics, resulting in significant improvements in the tumor immunotherapy. However, appropriate design or engineering of nanoparticles will be needed to improve delivery efficiency of antigen, adjuvant and therapeutics, resulting in eliciting antitumor immunity. Here, we review the current state of the art of cancer immunotherapeutic strategies, mainly based on nanoparticles (NPs). This includes NP-based antigen/adjuvant delivery vehicles to draining lymph nodes, and tumor antigen-specific T-lymphocytes for cancer immunotherapy. Several NP-based examples are shown for immune checkpoint modulation and immunogenic cell death. These overall studies demonstrate the great potential of NPs in cancer immunotherapy. Finally, engineering NP strategies will provide great opportunities to improve therapeutic effects as well as optimization of treatment processes, allowing to meet the individual needs in the cancer immunotherapy.

Original languageEnglish
Pages (from-to)597-607
Number of pages11
JournalBiomaterials
Volume178
DOIs
Publication statusPublished - 2018 Sep 1

Keywords

  • Adjuvant delivery
  • Antigen delivery
  • Immune checkpoint
  • Immunotherapy
  • Nanoparticles

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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  • Cite this

    Yoon, H. Y., Selvan, S. T., Yang, Y., Kim, M. J., Yi, D. K., Kwon, I. C., & Kim, K. M. (2018). Engineering nanoparticle strategies for effective cancer immunotherapy. Biomaterials, 178, 597-607. https://doi.org/10.1016/j.biomaterials.2018.03.036