Englprognosis after implantation of cardioverter-defibrillators in Korean patients with Brugada syndrome

Myoung Kyun Son, Kyeongmin Byeon, Seung Jung Park, June Soo Kim, Gi Byoung Nam, Kee Joon Choi, You Ho Kim, Sang Weon Park, Young Hoon Kim, Hyung Wook Park, Jeong Gwan Cho, Young Keun On

Research output: Contribution to journalArticle

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Abstract

Purpose: Our study aims to analyze prognosis after implantable cardioverter-defibrillator (ICD) implantation in Korean patients with Brugada syndrome (BrS). Materials and Methods: This was a retrospective study of BrS patients implanted with an ICD at one of four centers in Korea between January 1998 and April 2012. Sixty-nine patients (68 males, 1 female) were implanted with an ICD based on aborted cardiac arrest (n=38, 55%), history of syncope (n=17, 25%), or induced ventricular tachyarrhythmia on electrophysiologic study in asymptomatic patients (n=14, 20%). A family history of sudden cardiac death and a spontaneous type 1 electrocardiography (ECG) were noted in 13 patients (19%) and 44 patients (64%), respectively. Results: During a mean follow-up of 59±46 months, 4.6±5.5 appropriate shocks were delivered in 19 patients (28%). Fourteen patients (20%) experienced 5.2±8.0 inappropriate shocks caused by supraventricular arrhythmia, lead failure, or abnormal sensing. Six patients were admitted for cardiac causes during follow-up, but no cardiac deaths occurred. An episode of aborted cardiac arrest was a significant predictor of appropriate shock, and the composite of cardiac events in the Cox proportional hazard model [hazard ratio (95% confidence interval) was 11.34 (1.31-97.94) and 4.78 (1.41-16.22), respectively]. However, a spontaneous type 1 ECG was not a predictor of cardiac events. Conclusion: Appropriate shock (28%) and inappropriate shock (20%) were noted during a mean follow-up of 59±46 months in Korean BrS patients implanted with an ICD. An episode of aborted cardiac arrest was the most powerful predictor of cardiac events.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalYonsei Medical Journal
Volume55
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Brugada Syndrome
Defibrillators
Implantable Defibrillators
Shock
Heart Arrest
Electrocardiography
Sudden Cardiac Death
Syncope
Korea
Proportional Hazards Models
Tachycardia
Cardiac Arrhythmias
Retrospective Studies
Confidence Intervals

Keywords

  • Brugada syndrome
  • Implantable cardioverter-defibrillator
  • Korea
  • Sudden death
  • Syncope

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Son, M. K., Byeon, K., Park, S. J., Kim, J. S., Nam, G. B., Choi, K. J., ... On, Y. K. (2014). Englprognosis after implantation of cardioverter-defibrillators in Korean patients with Brugada syndrome. Yonsei Medical Journal, 55(1), 37-45. https://doi.org/10.3349/ymj.2014.55.1.37

Englprognosis after implantation of cardioverter-defibrillators in Korean patients with Brugada syndrome. / Son, Myoung Kyun; Byeon, Kyeongmin; Park, Seung Jung; Kim, June Soo; Nam, Gi Byoung; Choi, Kee Joon; Kim, You Ho; Park, Sang Weon; Kim, Young Hoon; Park, Hyung Wook; Cho, Jeong Gwan; On, Young Keun.

In: Yonsei Medical Journal, Vol. 55, No. 1, 01.01.2014, p. 37-45.

Research output: Contribution to journalArticle

Son, MK, Byeon, K, Park, SJ, Kim, JS, Nam, GB, Choi, KJ, Kim, YH, Park, SW, Kim, YH, Park, HW, Cho, JG & On, YK 2014, 'Englprognosis after implantation of cardioverter-defibrillators in Korean patients with Brugada syndrome', Yonsei Medical Journal, vol. 55, no. 1, pp. 37-45. https://doi.org/10.3349/ymj.2014.55.1.37
Son, Myoung Kyun ; Byeon, Kyeongmin ; Park, Seung Jung ; Kim, June Soo ; Nam, Gi Byoung ; Choi, Kee Joon ; Kim, You Ho ; Park, Sang Weon ; Kim, Young Hoon ; Park, Hyung Wook ; Cho, Jeong Gwan ; On, Young Keun. / Englprognosis after implantation of cardioverter-defibrillators in Korean patients with Brugada syndrome. In: Yonsei Medical Journal. 2014 ; Vol. 55, No. 1. pp. 37-45.
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abstract = "Purpose: Our study aims to analyze prognosis after implantable cardioverter-defibrillator (ICD) implantation in Korean patients with Brugada syndrome (BrS). Materials and Methods: This was a retrospective study of BrS patients implanted with an ICD at one of four centers in Korea between January 1998 and April 2012. Sixty-nine patients (68 males, 1 female) were implanted with an ICD based on aborted cardiac arrest (n=38, 55{\%}), history of syncope (n=17, 25{\%}), or induced ventricular tachyarrhythmia on electrophysiologic study in asymptomatic patients (n=14, 20{\%}). A family history of sudden cardiac death and a spontaneous type 1 electrocardiography (ECG) were noted in 13 patients (19{\%}) and 44 patients (64{\%}), respectively. Results: During a mean follow-up of 59±46 months, 4.6±5.5 appropriate shocks were delivered in 19 patients (28{\%}). Fourteen patients (20{\%}) experienced 5.2±8.0 inappropriate shocks caused by supraventricular arrhythmia, lead failure, or abnormal sensing. Six patients were admitted for cardiac causes during follow-up, but no cardiac deaths occurred. An episode of aborted cardiac arrest was a significant predictor of appropriate shock, and the composite of cardiac events in the Cox proportional hazard model [hazard ratio (95{\%} confidence interval) was 11.34 (1.31-97.94) and 4.78 (1.41-16.22), respectively]. However, a spontaneous type 1 ECG was not a predictor of cardiac events. Conclusion: Appropriate shock (28{\%}) and inappropriate shock (20{\%}) were noted during a mean follow-up of 59±46 months in Korean BrS patients implanted with an ICD. An episode of aborted cardiac arrest was the most powerful predictor of cardiac events.",
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AU - Byeon, Kyeongmin

AU - Park, Seung Jung

AU - Kim, June Soo

AU - Nam, Gi Byoung

AU - Choi, Kee Joon

AU - Kim, You Ho

AU - Park, Sang Weon

AU - Kim, Young Hoon

AU - Park, Hyung Wook

AU - Cho, Jeong Gwan

AU - On, Young Keun

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N2 - Purpose: Our study aims to analyze prognosis after implantable cardioverter-defibrillator (ICD) implantation in Korean patients with Brugada syndrome (BrS). Materials and Methods: This was a retrospective study of BrS patients implanted with an ICD at one of four centers in Korea between January 1998 and April 2012. Sixty-nine patients (68 males, 1 female) were implanted with an ICD based on aborted cardiac arrest (n=38, 55%), history of syncope (n=17, 25%), or induced ventricular tachyarrhythmia on electrophysiologic study in asymptomatic patients (n=14, 20%). A family history of sudden cardiac death and a spontaneous type 1 electrocardiography (ECG) were noted in 13 patients (19%) and 44 patients (64%), respectively. Results: During a mean follow-up of 59±46 months, 4.6±5.5 appropriate shocks were delivered in 19 patients (28%). Fourteen patients (20%) experienced 5.2±8.0 inappropriate shocks caused by supraventricular arrhythmia, lead failure, or abnormal sensing. Six patients were admitted for cardiac causes during follow-up, but no cardiac deaths occurred. An episode of aborted cardiac arrest was a significant predictor of appropriate shock, and the composite of cardiac events in the Cox proportional hazard model [hazard ratio (95% confidence interval) was 11.34 (1.31-97.94) and 4.78 (1.41-16.22), respectively]. However, a spontaneous type 1 ECG was not a predictor of cardiac events. Conclusion: Appropriate shock (28%) and inappropriate shock (20%) were noted during a mean follow-up of 59±46 months in Korean BrS patients implanted with an ICD. An episode of aborted cardiac arrest was the most powerful predictor of cardiac events.

AB - Purpose: Our study aims to analyze prognosis after implantable cardioverter-defibrillator (ICD) implantation in Korean patients with Brugada syndrome (BrS). Materials and Methods: This was a retrospective study of BrS patients implanted with an ICD at one of four centers in Korea between January 1998 and April 2012. Sixty-nine patients (68 males, 1 female) were implanted with an ICD based on aborted cardiac arrest (n=38, 55%), history of syncope (n=17, 25%), or induced ventricular tachyarrhythmia on electrophysiologic study in asymptomatic patients (n=14, 20%). A family history of sudden cardiac death and a spontaneous type 1 electrocardiography (ECG) were noted in 13 patients (19%) and 44 patients (64%), respectively. Results: During a mean follow-up of 59±46 months, 4.6±5.5 appropriate shocks were delivered in 19 patients (28%). Fourteen patients (20%) experienced 5.2±8.0 inappropriate shocks caused by supraventricular arrhythmia, lead failure, or abnormal sensing. Six patients were admitted for cardiac causes during follow-up, but no cardiac deaths occurred. An episode of aborted cardiac arrest was a significant predictor of appropriate shock, and the composite of cardiac events in the Cox proportional hazard model [hazard ratio (95% confidence interval) was 11.34 (1.31-97.94) and 4.78 (1.41-16.22), respectively]. However, a spontaneous type 1 ECG was not a predictor of cardiac events. Conclusion: Appropriate shock (28%) and inappropriate shock (20%) were noted during a mean follow-up of 59±46 months in Korean BrS patients implanted with an ICD. An episode of aborted cardiac arrest was the most powerful predictor of cardiac events.

KW - Brugada syndrome

KW - Implantable cardioverter-defibrillator

KW - Korea

KW - Sudden death

KW - Syncope

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