Englprognosis after implantation of cardioverter-defibrillators in Korean patients with Brugada syndrome

Myoung Kyun Son, Kyeongmin Byeon, Seung Jung Park, June Soo Kim, Gi Byoung Nam, Kee Joon Choi, You Ho Kim, Sang Weon Park, Young Hoon Kim, Hyung Wook Park, Jeong Gwan Cho, Young Keun On

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Purpose: Our study aims to analyze prognosis after implantable cardioverter-defibrillator (ICD) implantation in Korean patients with Brugada syndrome (BrS). Materials and Methods: This was a retrospective study of BrS patients implanted with an ICD at one of four centers in Korea between January 1998 and April 2012. Sixty-nine patients (68 males, 1 female) were implanted with an ICD based on aborted cardiac arrest (n=38, 55%), history of syncope (n=17, 25%), or induced ventricular tachyarrhythmia on electrophysiologic study in asymptomatic patients (n=14, 20%). A family history of sudden cardiac death and a spontaneous type 1 electrocardiography (ECG) were noted in 13 patients (19%) and 44 patients (64%), respectively. Results: During a mean follow-up of 59±46 months, 4.6±5.5 appropriate shocks were delivered in 19 patients (28%). Fourteen patients (20%) experienced 5.2±8.0 inappropriate shocks caused by supraventricular arrhythmia, lead failure, or abnormal sensing. Six patients were admitted for cardiac causes during follow-up, but no cardiac deaths occurred. An episode of aborted cardiac arrest was a significant predictor of appropriate shock, and the composite of cardiac events in the Cox proportional hazard model [hazard ratio (95% confidence interval) was 11.34 (1.31-97.94) and 4.78 (1.41-16.22), respectively]. However, a spontaneous type 1 ECG was not a predictor of cardiac events. Conclusion: Appropriate shock (28%) and inappropriate shock (20%) were noted during a mean follow-up of 59±46 months in Korean BrS patients implanted with an ICD. An episode of aborted cardiac arrest was the most powerful predictor of cardiac events.

    Original languageEnglish
    Pages (from-to)37-45
    Number of pages9
    JournalYonsei medical journal
    Volume55
    Issue number1
    DOIs
    Publication statusPublished - 2014 Jan

    Keywords

    • Brugada syndrome
    • Implantable cardioverter-defibrillator
    • Korea
    • Sudden death
    • Syncope

    ASJC Scopus subject areas

    • Medicine(all)

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