Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells

Ding Ding Guo, Hyun Seuk Moon, Rohidas Arote, Ji Hye Seo, Ji Shan Quan, Yun Jaie Choi, Chong Su Cho

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

This study is designed to evaluate whether conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) enhances anticancer efficacy in MCF-7 breast cancer cells when compared to conjugated linoleic acid (CLA) itself. CLA was simply coupled to Pluronic F127 through ester linkage between carboxyl group of CLA and hydroxyl one of Pluronic at melting state without solvent or catalyst. Plu-CLA significantly enhanced apoptosis with increasing concentration compared with CLA itself. Moreover, it was found that p53, p21, and Bax were up-regulated, whereas Bcl-2 and procaspase 9 were down-regulated with increasing concentration of Plu-CLA. These results were attributed to the sensitization activity of Pluronic F127.

Original languageEnglish
Pages (from-to)244-254
Number of pages11
JournalCancer letters
Volume254
Issue number2
DOIs
Publication statusPublished - 2007 Sep 8

Keywords

  • Apoptosis
  • Conjugated linoleic acid (CLA)
  • Pluronic F127
  • Polymer conjugation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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