Abstract
An aqueous dispersion of alpha-lipoic acid (ALA) using octenylsuccinic anhydride-modified high-amylose starch (OS) was prepared, and thermal stability and cellular bioavailability of ALA were compared with those prepared using native high-amylose starch (HA) and beta-cyclodextrin (β-CD). The ALA was homogeneously dispersed via the encapsulation of V-type amylose helices. In comparison with HA and β-CD, OS exhibited a higher ALA absorption in Caco-2 cells, indicating the OS facilitated the intestinal epithelial transport of ALA. Oral administration of the encapsulated ALA in-vivo resulted in a higher maximum ALA plasma concentration and extended the terminal half-life by 30–40%. The area under the plasma concentration vs. time for the administration of ALA complexed by OS was 50% larger than that by HA, indicating the effectiveness of OS in enhancing the oral bioavailability of ALA. These results indicate that OS is an efficient carrier for ALA in oral delivery and bioavailability.
| Original language | English |
|---|---|
| Pages (from-to) | 39-45 |
| Number of pages | 7 |
| Journal | Carbohydrate Polymers |
| Volume | 219 |
| DOIs | |
| Publication status | Published - 2019 Sep 1 |
Fingerprint
Keywords
- Alpha-lipoic acid
- Bioavailability
- Cellular absorption
- Encapsulation
- Octenylsuccinylated high-amylose starch
- V-type complex
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry
Cite this
Enhanced bioavailability of alpha-lipoic acid by complex formation with octenylsuccinylated high-amylose starch. / Li, Yi Xuan; Kim, Yeon Ji; Reddy, Chagam Koteswara; Lee, Sung-Joon; Lim, Seung Taik.
In: Carbohydrate Polymers, Vol. 219, 01.09.2019, p. 39-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhanced bioavailability of alpha-lipoic acid by complex formation with octenylsuccinylated high-amylose starch
AU - Li, Yi Xuan
AU - Kim, Yeon Ji
AU - Reddy, Chagam Koteswara
AU - Lee, Sung-Joon
AU - Lim, Seung Taik
PY - 2019/9/1
Y1 - 2019/9/1
N2 - An aqueous dispersion of alpha-lipoic acid (ALA) using octenylsuccinic anhydride-modified high-amylose starch (OS) was prepared, and thermal stability and cellular bioavailability of ALA were compared with those prepared using native high-amylose starch (HA) and beta-cyclodextrin (β-CD). The ALA was homogeneously dispersed via the encapsulation of V-type amylose helices. In comparison with HA and β-CD, OS exhibited a higher ALA absorption in Caco-2 cells, indicating the OS facilitated the intestinal epithelial transport of ALA. Oral administration of the encapsulated ALA in-vivo resulted in a higher maximum ALA plasma concentration and extended the terminal half-life by 30–40%. The area under the plasma concentration vs. time for the administration of ALA complexed by OS was 50% larger than that by HA, indicating the effectiveness of OS in enhancing the oral bioavailability of ALA. These results indicate that OS is an efficient carrier for ALA in oral delivery and bioavailability.
AB - An aqueous dispersion of alpha-lipoic acid (ALA) using octenylsuccinic anhydride-modified high-amylose starch (OS) was prepared, and thermal stability and cellular bioavailability of ALA were compared with those prepared using native high-amylose starch (HA) and beta-cyclodextrin (β-CD). The ALA was homogeneously dispersed via the encapsulation of V-type amylose helices. In comparison with HA and β-CD, OS exhibited a higher ALA absorption in Caco-2 cells, indicating the OS facilitated the intestinal epithelial transport of ALA. Oral administration of the encapsulated ALA in-vivo resulted in a higher maximum ALA plasma concentration and extended the terminal half-life by 30–40%. The area under the plasma concentration vs. time for the administration of ALA complexed by OS was 50% larger than that by HA, indicating the effectiveness of OS in enhancing the oral bioavailability of ALA. These results indicate that OS is an efficient carrier for ALA in oral delivery and bioavailability.
KW - Alpha-lipoic acid
KW - Bioavailability
KW - Cellular absorption
KW - Encapsulation
KW - Octenylsuccinylated high-amylose starch
KW - V-type complex
UR - http://www.scopus.com/inward/record.url?scp=85065448080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065448080&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2019.04.082
DO - 10.1016/j.carbpol.2019.04.082
M3 - Article
C2 - 31151539
AN - SCOPUS:85065448080
VL - 219
SP - 39
EP - 45
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
SN - 0144-8617
ER -