Enhanced biocompatibility and wound healing properties of biodegradable polymer-modified allyl 2-cyanoacrylate tissue adhesive

Young Ju Lee, Ho Sung Son, Gyeong Bok Jung, Ji Hye Kim, Samjin Choi, Gi Ja Lee, Hun Kuk Park

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

As poly L-lactic acid (PLLA) is a polymer with good biocompatibility and biodegradability, we created a new tissue adhesive (TA), pre-polymerized allyl 2-cyanoacrylate (PACA) mixed with PLLA in an effort to improve biocompatibility and mechanical properties in healing dermal wound tissue. We determined optimal mixing ratios of PACA and PLLA based on their bond strengths and chemical structures analyzed by the thermal gravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. In vitro biocompatibility of the PACA/PLLA was evaluated using direct- and indirect-contact methods according to the ISO-10993 cytotoxicity test for medical devices. The PACA/PLLA have similar or even better biocompatibility than those of commercially available cyanoacrylate (CA)-based TAs such as Dermabond® and Histoacryl®. The PACA/PLLA were not different from those exposed to Dermabond® and Histoacryl® in Raman spectra when biochemical changes of protein and DNA/RNA underlying during cell death were compared utilizing Raman spectroscopy. Histological analysis revealed that incised dermal tissues of rats treated with PACA/PLLA showed less inflammatory signs and enhanced collagen formation compared to those treated with Dermabond® or Histoacryl®. Of note, tissues treated with PACA/PLLA were stronger in the tensile strength compared to those treated with the commercially available TAs. Therefore, taking all the results into consideration, the PACA/PLLA we created might be a clinically useful TA for treating dermal wounds.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalMaterials Science and Engineering C
Volume51
DOIs
Publication statusPublished - 2015 Jun 1

Fingerprint

Tissue Adhesives
Cyanoacrylates
wound healing
Biodegradable polymers
lactic acid
healing
biocompatibility
Lactic acid
Biocompatibility
adhesives
Adhesives
Tissue
polymers
Enbucrilate
biodegradability
poly(lactic acid)
Gravimetric analysis
Biodegradability
Cell death
collagens

Keywords

  • Biocompatibility
  • Bond strength
  • Mechanical strength
  • Pre-polymerized allyl 2-cyanoacrylate (PACA)/poly L-lactic acid (PLLA)
  • Tissue adhesive
  • Wound healing

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Enhanced biocompatibility and wound healing properties of biodegradable polymer-modified allyl 2-cyanoacrylate tissue adhesive. / Lee, Young Ju; Son, Ho Sung; Jung, Gyeong Bok; Kim, Ji Hye; Choi, Samjin; Lee, Gi Ja; Park, Hun Kuk.

In: Materials Science and Engineering C, Vol. 51, 01.06.2015, p. 43-50.

Research output: Contribution to journalArticle

Lee, Young Ju ; Son, Ho Sung ; Jung, Gyeong Bok ; Kim, Ji Hye ; Choi, Samjin ; Lee, Gi Ja ; Park, Hun Kuk. / Enhanced biocompatibility and wound healing properties of biodegradable polymer-modified allyl 2-cyanoacrylate tissue adhesive. In: Materials Science and Engineering C. 2015 ; Vol. 51. pp. 43-50.
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