Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice

Kisun Jun, Gildon Choi, Sung Gu Yang, Kwan Yong Choi, Hyun Kim, Guy C K Chan, Daniel R. Storm, Claudia Albert, Georg W. Mayr, Chang Joong Lee, Hee Sup Shin

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Abstract

To define the physiological role of IP33-kinase(A) in vivo, we have generated a mouse strain with a null mutation of the IP33-kinase(A) locus by gene targeting. Homozygous mutant mice were fully viable, fertile, apparently normal, and did not show any morphological anomaly in brain sections. In the mutant brain, the IP4 level was significantly decreased whereas the IP3 level did not change, demonstrating a major role of IP33-kinase(A) in the generation of IP4. Nevertheless, no significant difference was detected in the hippocampal neuronal cells of the wild-type and the mutant mice in the kinetics of Ca2+ regulation after glutamate stimulation. Electrophysiological analyses carried out in hippocampal slices showed that the mutation significantly enhanced the LTP in the hippocampal CA1 region, but had no effect on the LTP in dentate gyrus (DG). No difference was noted, however, between the mutant and the wild-type mice in the Morris water maze task. Our results indicate that IP33-kinase(A) may play an important role in the regulation of LTP in hippocampal CA1 region through the generation of IP4, but the enhanced LTP in the hippocampal CA1 does not affect spatial learning and memory.

Original languageEnglish
Pages (from-to)317-330
Number of pages14
JournalLearning and Memory
Volume5
Issue number4-5
Publication statusPublished - 1998 Dec 1

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jun, K., Choi, G., Yang, S. G., Choi, K. Y., Kim, H., Chan, G. C. K., Storm, D. R., Albert, C., Mayr, G. W., Lee, C. J., & Shin, H. S. (1998). Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice. Learning and Memory, 5(4-5), 317-330.