Enhanced hypoglycemic activity following intratracheal administration of insulin microcrystal suspension with injection adjuvant

Hyun Kyung Lee, Jai Hyun Kwon, Sang H. Park, Chan Wha Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The pulmonary route appears to be the most attractive alternative for non-invasive systemic delivery of insulin. We have shown the feasibility of insulin microcrystals as a long-acting formulation for pulmonary delivery. In this study, we examined the effects of adjuvant for pulmonary formulations of insulin, such as protamine, zinc, and glycerol. In an in vivo experiment with rats, only zinc enhanced the hypoglycemic effect of insulin microcrystals, with 17% of minimum reductions in blood glucose (%MRBG) and a 44% decrement in the blood glucose level (D%9h).

Original languageEnglish
Pages (from-to)1003-1005
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume70
Issue number4
DOIs
Publication statusPublished - 2006 May 5

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Keywords

  • Adjuvant
  • Instillation
  • Insulin
  • Lung
  • Microcrystal

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Bioengineering
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology

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