Enhanced IL-18 expression in common skin tumors

Hyunjeong Park, Daegyoo Byun, Tae Sung Kim, Young I. Kim, Jae S. Kang, Eun S. Hahm, Seong H. Kim, Wang J. Lee, Hyun K. Song, Do Y. Yoon, Chang J. Kang, Changnam Lee, Dong Houh, Hyungok Kim, Baikkee Cho, Youngsill Kim, Yool H. Yang, Kyung H. Min, Dae Ho Cho

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Interleukin-18 (IL-18) has been found to have multiple effects upon various cells involved in inflammatory response. Recently we reported that B16 murine melanoma cells are able to produce IL-18, which is involved in the regulation of intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, indicating that IL-18 plays key role in the tumor activity of melanoma. In this study, we investigated the pattern of IL-18 expression in the human system. IL-18 production was tested by enzyme linked immunosorbent assay (ELISA) assay in various tumor cell lines, including Raji (Burkett's lymphoma), IM-9 (B lymphoblast), Jurkat (acute T cell leukemia), SK-MES-1 (squamous cell carcinoma (SCC) cell line), SK-MEL-2, G-361, DM-4, and DX-3 (melanoma cell lines). ELISA tests showed that IL-18 was highly expressed in malignant skin tumors such as SK-MES-1, SK-MEL-2, G-361, DM-4, and DX-3 cell lines, thus suggesting that IL-18 production may be associated with the malignancy of skin tumors. Here, we report that enhanced IL-18 expression is positively correlated with malignant skin tumors such as SCC and melanoma, suggesting the importance role of IL-18 in malignancy of skin tumors. Taken together, expression of IL-18 by tumor cells in human skin tissue may provide an important clue to understand the pathogenesis of malignant skin tumors.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalImmunology Letters
Volume79
Issue number3
DOIs
Publication statusPublished - 2001 Dec 3
Externally publishedYes

Keywords

  • IL-18
  • Skin tumors
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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  • Cite this

    Park, H., Byun, D., Kim, T. S., Kim, Y. I., Kang, J. S., Hahm, E. S., Kim, S. H., Lee, W. J., Song, H. K., Yoon, D. Y., Kang, C. J., Lee, C., Houh, D., Kim, H., Cho, B., Kim, Y., Yang, Y. H., Min, K. H., & Cho, D. H. (2001). Enhanced IL-18 expression in common skin tumors. Immunology Letters, 79(3), 215-219. https://doi.org/10.1016/S0165-2478(01)00278-4