Enhanced Mechanical Strength, Flexibility, and Shape-Restoring Rate of a Drug-Eluting Shape-Memory Polymer by Incorporation of Supramolecular Cross-Linkers

Jiae Seo, Jae Won Choi, Young Hag Koh, Ji Hun Seo

Research output: Contribution to journalArticle

Abstract

The purpose of this study is to develop mechanically robust soybean oil and polycaprolactone (PC)-based drug-eluting shape memory polymers (SMPs) containing polyrotaxane (PRX) cross-linkers. Essentially, the dynamic PRX cross-linker-containing methacrylate group is introduced to increase the cross-linking density and flexibility of the SMP to overcome its mechanical limitations. It was confirmed that the elongation and cross-linking density of the PRX-incorporated SMP were increased by 2-4 times compared to neat SMP. In addition, those high mechanical properties of the PRX-incorporated SMP could be maintained after the degradation of the PC by the drug-eluting process.

Original languageEnglish
Pages (from-to)389-395
Number of pages7
JournalACS Macro Letters
Volume9
Issue number3
DOIs
Publication statusPublished - 2020 Mar 17

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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