Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting

Hyo Sung Jung, Jiyou Han, Jae Hong Lee, Ji Ha Lee, Jong Min Choi, Hee Seok Kweon, Ji Hye Han, Jong-Hoon Kim, Kyung Min Byun, Jong Hwa Jung, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.

Original languageEnglish
Pages (from-to)3017-3023
Number of pages7
JournalJournal of the American Chemical Society
Volume137
Issue number8
DOIs
Publication statusPublished - 2015 Mar 4

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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    Jung, H. S., Han, J., Lee, J. H., Lee, J. H., Choi, J. M., Kweon, H. S., Han, J. H., Kim, J-H., Byun, K. M., Jung, J. H., Kang, C., & Kim, J. S. (2015). Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting. Journal of the American Chemical Society, 137(8), 3017-3023. https://doi.org/10.1021/ja5122809