Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting

Hyo Sung Jung, Jiyou Han, Jae Hong Lee, Ji Ha Lee, Jong Min Choi, Hee Seok Kweon, Ji Hye Han, Jong-Hoon Kim, Kyung Min Byun, Jong Hwa Jung, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.

Original languageEnglish
Pages (from-to)3017-3023
Number of pages7
JournalJournal of the American Chemical Society
Volume137
Issue number8
DOIs
Publication statusPublished - 2015 Mar 4

Fingerprint

Iron oxides
Mitochondria
Fever
Radiation
Laser beam effects
Cytotoxicity
HeLa Cells
Lasers
Temperature
Infrared lasers
Heterografts
Organelles
Nanoparticles
Tumors
Neoplasms
Cells
coumarin
ferric oxide
Therapeutics

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting. / Jung, Hyo Sung; Han, Jiyou; Lee, Jae Hong; Lee, Ji Ha; Choi, Jong Min; Kweon, Hee Seok; Han, Ji Hye; Kim, Jong-Hoon; Byun, Kyung Min; Jung, Jong Hwa; Kang, Chulhun; Kim, Jong Seung.

In: Journal of the American Chemical Society, Vol. 137, No. 8, 04.03.2015, p. 3017-3023.

Research output: Contribution to journalArticle

Jung, HS, Han, J, Lee, JH, Lee, JH, Choi, JM, Kweon, HS, Han, JH, Kim, J-H, Byun, KM, Jung, JH, Kang, C & Kim, JS 2015, 'Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting', Journal of the American Chemical Society, vol. 137, no. 8, pp. 3017-3023. https://doi.org/10.1021/ja5122809
Jung, Hyo Sung ; Han, Jiyou ; Lee, Jae Hong ; Lee, Ji Ha ; Choi, Jong Min ; Kweon, Hee Seok ; Han, Ji Hye ; Kim, Jong-Hoon ; Byun, Kyung Min ; Jung, Jong Hwa ; Kang, Chulhun ; Kim, Jong Seung. / Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting. In: Journal of the American Chemical Society. 2015 ; Vol. 137, No. 8. pp. 3017-3023.
@article{1ab9f0614f8c486a85bb2d0bcab6d2e1,
title = "Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting",
abstract = "Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.",
author = "Jung, {Hyo Sung} and Jiyou Han and Lee, {Jae Hong} and Lee, {Ji Ha} and Choi, {Jong Min} and Kweon, {Hee Seok} and Han, {Ji Hye} and Jong-Hoon Kim and Byun, {Kyung Min} and Jung, {Jong Hwa} and Chulhun Kang and Kim, {Jong Seung}",
year = "2015",
month = "3",
day = "4",
doi = "10.1021/ja5122809",
language = "English",
volume = "137",
pages = "3017--3023",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "8",

}

TY - JOUR

T1 - Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting

AU - Jung, Hyo Sung

AU - Han, Jiyou

AU - Lee, Jae Hong

AU - Lee, Ji Ha

AU - Choi, Jong Min

AU - Kweon, Hee Seok

AU - Han, Ji Hye

AU - Kim, Jong-Hoon

AU - Byun, Kyung Min

AU - Jung, Jong Hwa

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2015/3/4

Y1 - 2015/3/4

N2 - Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.

AB - Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=84924308454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924308454&partnerID=8YFLogxK

U2 - 10.1021/ja5122809

DO - 10.1021/ja5122809

M3 - Article

C2 - 25662739

AN - SCOPUS:84924308454

VL - 137

SP - 3017

EP - 3023

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 8

ER -