Abstract
Throughout life, new neurons are continuously generated from subventricular zone and added to the olfactory bulb (OB). Because a subset of mature OB neurons undergoes spontaneous cell death, adult OB neurogenesis serves for the replacement of this cell loss. Spontaneous cell turnover should alter the neuronal circuits, but the significance of cell turnover on olfactory learning is yet poorly understood. In this study, we explored the olfactory learning behaviors of model mice showing (1) absence of cell death and cell addition (aged Bax-KO mice); (2) absence of cell death but presence of cell addition (young Bax-KO mice); or (3) presence cell death but absence of cell addition (surgical lesion of rostral migratory stream of neuroblasts). Interestingly, aged Bax-KO mice with no cell replacement acquired the ability to discriminate odor differences faster than WT littermates, whereas other model mice exhibited virtually normal learning ability. These results suggest that the cell replacement is necessary for the normal olfactory learning behavior, and the chronic perturbation of cell replacement may result in the imbalance of neural circuits driving unexpected enhancement of olfactory learning ability.
| Original language | English |
|---|---|
| Pages (from-to) | 196-200 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 548 |
| DOIs | |
| Publication status | Published - 2013 Aug 26 |
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Keywords
- Adult neurogenesis
- Cell death
- Odor discrimination learning
- Olfactory bulb
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Enhanced odor discrimination learning in aged Bax-KO mice. / Kim, Woon Ryoung; Sun, Woong.
In: Neuroscience Letters, Vol. 548, 26.08.2013, p. 196-200.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhanced odor discrimination learning in aged Bax-KO mice
AU - Kim, Woon Ryoung
AU - Sun, Woong
PY - 2013/8/26
Y1 - 2013/8/26
N2 - Throughout life, new neurons are continuously generated from subventricular zone and added to the olfactory bulb (OB). Because a subset of mature OB neurons undergoes spontaneous cell death, adult OB neurogenesis serves for the replacement of this cell loss. Spontaneous cell turnover should alter the neuronal circuits, but the significance of cell turnover on olfactory learning is yet poorly understood. In this study, we explored the olfactory learning behaviors of model mice showing (1) absence of cell death and cell addition (aged Bax-KO mice); (2) absence of cell death but presence of cell addition (young Bax-KO mice); or (3) presence cell death but absence of cell addition (surgical lesion of rostral migratory stream of neuroblasts). Interestingly, aged Bax-KO mice with no cell replacement acquired the ability to discriminate odor differences faster than WT littermates, whereas other model mice exhibited virtually normal learning ability. These results suggest that the cell replacement is necessary for the normal olfactory learning behavior, and the chronic perturbation of cell replacement may result in the imbalance of neural circuits driving unexpected enhancement of olfactory learning ability.
AB - Throughout life, new neurons are continuously generated from subventricular zone and added to the olfactory bulb (OB). Because a subset of mature OB neurons undergoes spontaneous cell death, adult OB neurogenesis serves for the replacement of this cell loss. Spontaneous cell turnover should alter the neuronal circuits, but the significance of cell turnover on olfactory learning is yet poorly understood. In this study, we explored the olfactory learning behaviors of model mice showing (1) absence of cell death and cell addition (aged Bax-KO mice); (2) absence of cell death but presence of cell addition (young Bax-KO mice); or (3) presence cell death but absence of cell addition (surgical lesion of rostral migratory stream of neuroblasts). Interestingly, aged Bax-KO mice with no cell replacement acquired the ability to discriminate odor differences faster than WT littermates, whereas other model mice exhibited virtually normal learning ability. These results suggest that the cell replacement is necessary for the normal olfactory learning behavior, and the chronic perturbation of cell replacement may result in the imbalance of neural circuits driving unexpected enhancement of olfactory learning ability.
KW - Adult neurogenesis
KW - Cell death
KW - Odor discrimination learning
KW - Olfactory bulb
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U2 - 10.1016/j.neulet.2013.05.017
DO - 10.1016/j.neulet.2013.05.017
M3 - Article
C2 - 23685130
AN - SCOPUS:84880133224
VL - 548
SP - 196
EP - 200
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -