Enhanced payload and photo-protection for pesticides using nanostructured lipid carriers with corn oil as liquid lipid

H. M. Nguyen, I. C. Hwang, Jae W. Park, Hyun Jin Park

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

With the aim to establish a novel nanocarrier system with higher payload and higher photo-protection for deltamethrin (active ingredient) compared to solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) were prepared by combining hot homogenization and sonication with different ratios of corn oil (liquid lipid) and beeswax (solid lipid). Compared to SLN, the incorporation of corn oil gave a higher payload, slower release rate and higher photo-protection for deltamethrin. Particularly, compared to beeswax solid lipid nanoparticles (BSLN), NLC gave a higher payload (approximately 1.79 times) with a high encapsulation efficiency (83.6), higher photo-protection in direct photolysis (1.8 times) after 12h exposure of ultraviolet light (UV) and in indirect photolysis (1.37 times) after 2h exposure of UV in 2 (v/v) acetone solution used as a photosensitizer. This study demonstrated that novel nanocarrier possesses a wide range of applicability in protecting photo-labile compounds for the crop, food and pharmaceutical industries.

Original languageEnglish
Pages (from-to)596-604
Number of pages9
JournalJournal of Microencapsulation
Volume29
Issue number6
DOIs
Publication statusPublished - 2012 Sep 1

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Keywords

  • Beeswax
  • Corn oil
  • Deltamethrin
  • Nanostructured lipid carriers
  • Photo-protection

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Bioengineering
  • Organic Chemistry

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