TY - JOUR
T1 - Enhanced payload of lipid nanocarriers using supersaturated solution prepared by solvent-mediated method
AU - Nguyen, H. M.
AU - Hwang, I. C.
AU - Kweon, D. K.
AU - Park, H. J.
N1 - Funding Information:
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article. This study was partly supported by a Grant of Kyung-Nong Company and Korea University, Republic of Korea.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - With the aim to effectively enhance the payload for nanocarriers, supersaturated deltamethrin (SSD) solution was prepared using the solvent-mediated method to produce lipid nanocarriers by a combination method of homogenization and sonication. In this study, deltamethrin was used as an active ingredient, corn oil was used as a lipid medium, soybean lecithin and Tween-80 were used as surfactants. At 25°C, the solubility of deltamethrin in SSD solution prepared by solvent-mediated method was 3.4 times and 1.5 times higher than that in saturated deltamethrin (SD) solution and that in SSD solution prepared by thermal-mediated method, respectively. Therefore, compared to the use of SD solution for the production of nanocarriers, the use of SSD solution significantly enhanced the payload, while keeping the encapsulation efficiency high. Particularly, nanocarriers produced from SSD solution prepared by solvent-mediated method had the higher payload of 2.1 times and 4.4 times compared with preparations using SSD solution prepared by thermal-mediated method and SD solution, respectively.
AB - With the aim to effectively enhance the payload for nanocarriers, supersaturated deltamethrin (SSD) solution was prepared using the solvent-mediated method to produce lipid nanocarriers by a combination method of homogenization and sonication. In this study, deltamethrin was used as an active ingredient, corn oil was used as a lipid medium, soybean lecithin and Tween-80 were used as surfactants. At 25°C, the solubility of deltamethrin in SSD solution prepared by solvent-mediated method was 3.4 times and 1.5 times higher than that in saturated deltamethrin (SD) solution and that in SSD solution prepared by thermal-mediated method, respectively. Therefore, compared to the use of SD solution for the production of nanocarriers, the use of SSD solution significantly enhanced the payload, while keeping the encapsulation efficiency high. Particularly, nanocarriers produced from SSD solution prepared by solvent-mediated method had the higher payload of 2.1 times and 4.4 times compared with preparations using SSD solution prepared by thermal-mediated method and SD solution, respectively.
KW - Corn oil
KW - Deltamethrin
KW - Payload
KW - Soybean lecithin
KW - Supersaturated deltamethrin solution
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U2 - 10.3109/02652048.2013.774445
DO - 10.3109/02652048.2013.774445
M3 - Article
C2 - 23425086
AN - SCOPUS:84885341859
VL - 30
SP - 657
EP - 666
JO - Journal of Microencapsulation
JF - Journal of Microencapsulation
SN - 0265-2048
IS - 7
ER -