Abstract
With the aim to effectively enhance the payload for nanocarriers, supersaturated deltamethrin (SSD) solution was prepared using the solvent-mediated method to produce lipid nanocarriers by a combination method of homogenization and sonication. In this study, deltamethrin was used as an active ingredient, corn oil was used as a lipid medium, soybean lecithin and Tween-80 were used as surfactants. At 25°C, the solubility of deltamethrin in SSD solution prepared by solvent-mediated method was 3.4 times and 1.5 times higher than that in saturated deltamethrin (SD) solution and that in SSD solution prepared by thermal-mediated method, respectively. Therefore, compared to the use of SD solution for the production of nanocarriers, the use of SSD solution significantly enhanced the payload, while keeping the encapsulation efficiency high. Particularly, nanocarriers produced from SSD solution prepared by solvent-mediated method had the higher payload of 2.1 times and 4.4 times compared with preparations using SSD solution prepared by thermal-mediated method and SD solution, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 657-666 |
| Number of pages | 10 |
| Journal | Journal of Microencapsulation |
| Volume | 30 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2013 Oct 16 |
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Keywords
- Corn oil
- Deltamethrin
- Payload
- Soybean lecithin
- Supersaturated deltamethrin solution
ASJC Scopus subject areas
- Pharmaceutical Science
- Colloid and Surface Chemistry
- Physical and Theoretical Chemistry
- Bioengineering
- Organic Chemistry
Cite this
Enhanced payload of lipid nanocarriers using supersaturated solution prepared by solvent-mediated method. / Nguyen, H. M.; Hwang, I. C.; Kweon, D. K.; Park, Hyun Jin.
In: Journal of Microencapsulation, Vol. 30, No. 7, 16.10.2013, p. 657-666.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhanced payload of lipid nanocarriers using supersaturated solution prepared by solvent-mediated method
AU - Nguyen, H. M.
AU - Hwang, I. C.
AU - Kweon, D. K.
AU - Park, Hyun Jin
PY - 2013/10/16
Y1 - 2013/10/16
N2 - With the aim to effectively enhance the payload for nanocarriers, supersaturated deltamethrin (SSD) solution was prepared using the solvent-mediated method to produce lipid nanocarriers by a combination method of homogenization and sonication. In this study, deltamethrin was used as an active ingredient, corn oil was used as a lipid medium, soybean lecithin and Tween-80 were used as surfactants. At 25°C, the solubility of deltamethrin in SSD solution prepared by solvent-mediated method was 3.4 times and 1.5 times higher than that in saturated deltamethrin (SD) solution and that in SSD solution prepared by thermal-mediated method, respectively. Therefore, compared to the use of SD solution for the production of nanocarriers, the use of SSD solution significantly enhanced the payload, while keeping the encapsulation efficiency high. Particularly, nanocarriers produced from SSD solution prepared by solvent-mediated method had the higher payload of 2.1 times and 4.4 times compared with preparations using SSD solution prepared by thermal-mediated method and SD solution, respectively.
AB - With the aim to effectively enhance the payload for nanocarriers, supersaturated deltamethrin (SSD) solution was prepared using the solvent-mediated method to produce lipid nanocarriers by a combination method of homogenization and sonication. In this study, deltamethrin was used as an active ingredient, corn oil was used as a lipid medium, soybean lecithin and Tween-80 were used as surfactants. At 25°C, the solubility of deltamethrin in SSD solution prepared by solvent-mediated method was 3.4 times and 1.5 times higher than that in saturated deltamethrin (SD) solution and that in SSD solution prepared by thermal-mediated method, respectively. Therefore, compared to the use of SD solution for the production of nanocarriers, the use of SSD solution significantly enhanced the payload, while keeping the encapsulation efficiency high. Particularly, nanocarriers produced from SSD solution prepared by solvent-mediated method had the higher payload of 2.1 times and 4.4 times compared with preparations using SSD solution prepared by thermal-mediated method and SD solution, respectively.
KW - Corn oil
KW - Deltamethrin
KW - Payload
KW - Soybean lecithin
KW - Supersaturated deltamethrin solution
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UR - http://www.scopus.com/inward/citedby.url?scp=84885341859&partnerID=8YFLogxK
U2 - 10.3109/02652048.2013.774445
DO - 10.3109/02652048.2013.774445
M3 - Article
C2 - 23425086
AN - SCOPUS:84885341859
VL - 30
SP - 657
EP - 666
JO - Journal of Microencapsulation
JF - Journal of Microencapsulation
SN - 0265-2048
IS - 7
ER -