Enhanced payload of lipid nanocarriers using supersaturated solution prepared by solvent-mediated method

H. M. Nguyen, I. C. Hwang, D. K. Kweon, Hyun Jin Park

Research output: Contribution to journalArticle

1 Citation (Scopus)


With the aim to effectively enhance the payload for nanocarriers, supersaturated deltamethrin (SSD) solution was prepared using the solvent-mediated method to produce lipid nanocarriers by a combination method of homogenization and sonication. In this study, deltamethrin was used as an active ingredient, corn oil was used as a lipid medium, soybean lecithin and Tween-80 were used as surfactants. At 25°C, the solubility of deltamethrin in SSD solution prepared by solvent-mediated method was 3.4 times and 1.5 times higher than that in saturated deltamethrin (SD) solution and that in SSD solution prepared by thermal-mediated method, respectively. Therefore, compared to the use of SD solution for the production of nanocarriers, the use of SSD solution significantly enhanced the payload, while keeping the encapsulation efficiency high. Particularly, nanocarriers produced from SSD solution prepared by solvent-mediated method had the higher payload of 2.1 times and 4.4 times compared with preparations using SSD solution prepared by thermal-mediated method and SD solution, respectively.

Original languageEnglish
Pages (from-to)657-666
Number of pages10
JournalJournal of Microencapsulation
Issue number7
Publication statusPublished - 2013 Oct 16



  • Corn oil
  • Deltamethrin
  • Payload
  • Soybean lecithin
  • Supersaturated deltamethrin solution

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Bioengineering
  • Organic Chemistry

Cite this