Enhanced performance of fluorine substituted hydroxyapatite composites for hard tissue engineering

Hae W. Kim, Yoon Jung Noh, Young-Hag Koh, Hyoun E. Kim

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Dense fluorine (F) substituted hydroxyapatite composites with yttria-doped zirconia (Y-TZP) and/or alumina (Al2O3) were successfully fabricated without applying pressure at 1400°C for 3 h. The suppression of decomposition via the formation of a fluor-hydroxyapatite (FHA) solid solution allowed the sintered body to reach full density. Such fully densified FHA-composites exhibited improved mechanical properties, such as strength, toughness, and hardness, having values of more than ∼ 2-4 times higher than those of pure HA or HA-composites. The proliferation behavior of osteoblast-like cells on the FHA-composites showed no cytotoxicity and comparable cell viability to that observed in pure HA for up to 10 days.

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Volume14
Issue number10
DOIs
Publication statusPublished - 2003 Oct 1
Externally publishedYes

Fingerprint

Fluorine
tissue engineering
Durapatite
Tissue Engineering
Hydroxyapatite
Tissue engineering
fluorine
composite materials
Composite materials
Aluminum Oxide
Cells
Hardness
Osteoblasts
osteoblasts
Yttrium oxide
Cell Survival
toughness
Cytotoxicity
viability
zirconium oxides

ASJC Scopus subject areas

  • Biophysics
  • Chemical Engineering(all)
  • Bioengineering

Cite this

Enhanced performance of fluorine substituted hydroxyapatite composites for hard tissue engineering. / Kim, Hae W.; Noh, Yoon Jung; Koh, Young-Hag; Kim, Hyoun E.

In: Journal of Materials Science: Materials in Medicine, Vol. 14, No. 10, 01.10.2003, p. 899-904.

Research output: Contribution to journalArticle

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