Enhanced performance of fluorine substituted hydroxyapatite composites for hard tissue engineering

Hae Won Kim, Yoon Jung Noh, Young Hag Koh, Hyoun Ee Kim

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Dense fluorine (F) substituted hydroxyapatite composites with yttria-doped zirconia (Y-TZP) and/or alumina (Al2O3) were successfully fabricated without applying pressure at 1400°C for 3 h. The suppression of decomposition via the formation of a fluor-hydroxyapatite (FHA) solid solution allowed the sintered body to reach full density. Such fully densified FHA-composites exhibited improved mechanical properties, such as strength, toughness, and hardness, having values of more than ∼ 2-4 times higher than those of pure HA or HA-composites. The proliferation behavior of osteoblast-like cells on the FHA-composites showed no cytotoxicity and comparable cell viability to that observed in pure HA for up to 10 days.

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Volume14
Issue number10
DOIs
Publication statusPublished - 2003 Oct 1

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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