Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids

Bok Hwan Chun, Song Yong Park, Namhyun Chung, Won G. Bang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalBiotechnology Letters
Volume25
Issue number4
DOIs
Publication statusPublished - 2003 Feb 1

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Keywords

  • Alkanoic acid
  • Factor VIII
  • Protein-free medium
  • Sodium butyrate
  • Sodium propionate

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Microbiology

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