Enhanced proliferation of progenitor cells following long-term potentiation induction in the rat dentate gyrus

Sung Kun Chun, Woong Sun, Joong Jean Park, Min Whan Jung

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The dentate gyrus (DG) is among the few areas in the mammalian brain where production of new neurons continues in the adulthood. Although its functional significance is not completely understood, several lines of evidence suggest the role of DG neurogenesis in learning and memory. Considering that long-term potentiation (LTP) is a prime candidate for the process underlying hippocampal learning and memory, these results raise the possibility that LTP and neurogenesis are closely related. Here, we investigated whether or not LTP induction in the afferent pathway triggers enhanced proliferation of progenitor cells in the DG. LTP was induced by tetanic stimulation in perforant path-DG synapses in one hemisphere, and the number of newly generated progenitor (BrdU-labeled) cells in the DG was quantified. Compared with the control hemisphere (stimulated with low-frequency pulses), the LTP-induced hemisphere contained a significantly higher number of newly generated progenitor cells in the dorsal as well as ventral DG. When CPP, an NMDA receptor antagonist, was administered, tetanic stimulation neither induced LTP nor enhanced progenitor cell proliferation, indicating that NMDA receptor activation, rather than tetanic stimulation per se, is responsible for enhanced progenitor proliferation in the control animal. Our results show that tetanic stimulation of perforant path sufficient to induce LTP increases progenitor proliferation in adult DG in an NMDA receptor-dependent manner.

Original languageEnglish
Pages (from-to)322-329
Number of pages8
JournalNeurobiology of Learning and Memory
Volume86
Issue number3
DOIs
Publication statusPublished - 2006 Nov 1

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Long-Term Potentiation
Dentate Gyrus
Stem Cells
N-Methyl-D-Aspartate Receptors
Perforant Pathway
Neurogenesis
Learning
Afferent Pathways
Bromodeoxyuridine
Synapses
Cell Proliferation
Neurons
Brain

Keywords

  • BrdU labeling
  • LTP
  • Neural stem cell
  • Neurogenesis
  • NMDA receptor
  • Subgranular zone

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Enhanced proliferation of progenitor cells following long-term potentiation induction in the rat dentate gyrus. / Chun, Sung Kun; Sun, Woong; Park, Joong Jean; Jung, Min Whan.

In: Neurobiology of Learning and Memory, Vol. 86, No. 3, 01.11.2006, p. 322-329.

Research output: Contribution to journalArticle

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