Various image re-coloring methods have been developed to enhance the perceptibility of the image for the color-blind. Recently, some methods have been proposed to produce the re-colored images that are not only visually perceptible for color deficient viewers but also look natural for normal observer. However, the methods are impractical to apply to the consumer devices due to its high complexity. Therefore, in this paper, an efficient re-coloring method that utilizes color clustering is proposed. The proposed method detects visually important region to further enhance perceptibility of re-colored images. Experimental results show that the proposed method can provide more comprehensible images for the color-blind person while maintaining the original color information.