Enhanced resolution of a surface plasmon resonance sensor detecting C-reactive protein via a bimetallic waveguide-coupled mode approach

Hwa Seub Lee, Tae Yeon Seong, Won Mok Kim, Inho Kim, Gyu Weon Hwang, Wook Seong Lee, Kyeong Seok Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Extensive efforts have been devoted to improving the resolution of surface plasmon resonance (SPR) sensors in the detection of trace levels of biomolecules considered essential for the early diagnosis of disease. As part of these efforts, we previously developed a bimetallic waveguide-coupled surface plasmon resonance (Bi-WCSPR) sensor configuration designed to dramatically reduce the linewidth of the SPR curve while preserving a moderate local field decay length, thereby addressing the resolution issue. In this study, we systematically quantified the enhanced resolution in Bi-WCSPR sensors used to detect C-reactive protein (CRP), a widely accepted biomarker of inflammation in cardiovascular disease. Individual SPR sensorgrams were measured at several CRP concentrations in both the intensity and angular interrogation modes, confirming that the Bi-WCSPR configuration with a high Ag-to-Au ratio provided a figure-of-merit (FOM) that was 2.53 times higher than that of conventional Au sensors and a limit-of-detection (LOD) that was an order of magnitude lower than the cut-off level for CRP. It was found that when using the Bi-WCSPR configurations, the resolution enhancement in the intensity interrogation mode becomes more evident as the CRP concentrations is lowered to the cut-off level.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalSensors and Actuators, B: Chemical
Volume266
DOIs
Publication statusPublished - 2018 Aug 1

Fingerprint

Surface plasmon resonance
surface plasmon resonance
C-Reactive Protein
coupled modes
Waveguides
waveguides
proteins
Proteins
sensors
Sensors
interrogation
cut-off
configurations
biomarkers
Biomolecules
Biomarkers
figure of merit
Linewidth
preserving
augmentation

Keywords

  • Bimetallic waveguide-coupled surface plasmon resonance
  • C-reactive protein
  • Resolution enhancement
  • Surface plasmon resonance sensor

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

Enhanced resolution of a surface plasmon resonance sensor detecting C-reactive protein via a bimetallic waveguide-coupled mode approach. / Lee, Hwa Seub; Seong, Tae Yeon; Kim, Won Mok; Kim, Inho; Hwang, Gyu Weon; Lee, Wook Seong; Lee, Kyeong Seok.

In: Sensors and Actuators, B: Chemical, Vol. 266, 01.08.2018, p. 311-317.

Research output: Contribution to journalArticle

Lee, Hwa Seub ; Seong, Tae Yeon ; Kim, Won Mok ; Kim, Inho ; Hwang, Gyu Weon ; Lee, Wook Seong ; Lee, Kyeong Seok. / Enhanced resolution of a surface plasmon resonance sensor detecting C-reactive protein via a bimetallic waveguide-coupled mode approach. In: Sensors and Actuators, B: Chemical. 2018 ; Vol. 266. pp. 311-317.
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