Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer

Joo Heon Kim, Chang Nam Kim, Soo Young Kim, Jung Sam Lee, Dae Ho Cho, Jae Wha Kim, Sun Young Yoon

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To investigate the expression levels of S100A4 in human colorectal carcinoma (CC) and its relationship with clinicopathological parameters and metastatic potential, 73 pathological specimens from patients with CC were examined for S100A4 expression by RT-PCR and immunohistochemistry. An increase of S100A4 mRNA was observed in 19/23 (82.6%) CC specimens, and S100A4 was up-regulated in 40/73 (54.7%) CC cases compared with non-neoplastic mucosal tissues. Upregulation of S100A4 was significantly related to invasion, nodal status, distant metastasis and p53 expression. Next, we investigated whether S100A4 could affect p53 transactivation and stability. Interestingly, it was revealed that treatment with exogenous S100A4 protein reduced transcriptional activity of p53 and abrogated the modification of calcium binding affinity of S100A4 protein. These findings suggested that S100A4 might be involved in the progression and metastasis of human CC, presumably via modulation of the wild-type p53 protein.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalOncology Reports
Volume22
Issue number1
DOIs
Publication statusPublished - 2009 Aug 13
Externally publishedYes

Fingerprint

Colorectal Neoplasms
Neoplasm Metastasis
Transcriptional Activation
Mucous Membrane
Up-Regulation
Immunohistochemistry
S100 Calcium-Binding Protein A4
Calcium
Polymerase Chain Reaction
Messenger RNA
Proteins
Therapeutics

Keywords

  • Colorectal carcinoma
  • Metastasis
  • P53 transactivation
  • S100A4

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer. / Kim, Joo Heon; Kim, Chang Nam; Kim, Soo Young; Lee, Jung Sam; Cho, Dae Ho; Kim, Jae Wha; Yoon, Sun Young.

In: Oncology Reports, Vol. 22, No. 1, 13.08.2009, p. 41-47.

Research output: Contribution to journalArticle

Kim, Joo Heon ; Kim, Chang Nam ; Kim, Soo Young ; Lee, Jung Sam ; Cho, Dae Ho ; Kim, Jae Wha ; Yoon, Sun Young. / Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer. In: Oncology Reports. 2009 ; Vol. 22, No. 1. pp. 41-47.
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