Enhancement of chemotactic cell aggregation by haptotactic cell-to-cell interaction

Tae Goo Kwon, Taeseok Daniel Yang, Kyoung Jin Lee

Research output: Contribution to journalArticle

Abstract

The crawling of biological cell is a complex phenomenon involving various biochemical and mechanical processes. Some of these processes are intrinsic to individual cells, while others pertain to cell-to-cell interactions and to their responses to extrinsically imposed cues. Here, we report an interesting aggregation dynamics of mathematical model cells, when they perform chemotaxis in response to an externally imposed global chemical gradient while they influence each other through a haptotaxis-mediated social interaction, which confers intriguing trail patterns. In the absence of the cell-to-cell interaction, the equilibrium population density profile fits well to that of a simple Keller-Segal population dynamic model, in which a chemotactic current density J chemo ∼ ∇p competes with a normal diffusive current density J diff ∼ ∇ρ, where p and ρ refer to the concentration of chemoattractant and population density, respectively. We find that the cell-to-cell interaction confers a far more compact aggregation resulting in a much higher peak equilibrium cell density. The mathematical model system is applicable to many biological systems such as swarming microglia and neutrophils or accumulating ants towards a localized food source.

Original languageEnglish
Article numbere0154717
JournalPLoS One
Volume11
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

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Cell Aggregation
Cell Communication
Current density
Agglomeration
Chemotaxis
Mathematical models
Population Density
Population dynamics
Chemotactic Factors
Mechanical Phenomena
Biochemical Phenomena
Theoretical Models
Biological systems
Dynamic models
Ants
Population Dynamics
Microglia
cells
Interpersonal Relations
Cues

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Enhancement of chemotactic cell aggregation by haptotactic cell-to-cell interaction. / Kwon, Tae Goo; Yang, Taeseok Daniel; Lee, Kyoung Jin.

In: PLoS One, Vol. 11, No. 4, e0154717, 01.04.2016.

Research output: Contribution to journalArticle

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