Enhancement of Curcumin Solubility by Phase Change from Crystalline to Amorphous in Cur-TPGS Nanosuspension

Gye Hwa Shin, Jinglei Li, Jin Hun Cho, Jun Tae Kim, Hyun Jin Park

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Nanosuspensions (NSs) were fabricated to enhance water solubility, dissolution rate, and oral adsorption of water insoluble curcumin using sonoprecipitation method. As a good stabilizer, d-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) was used to improve the stability of curcumin-TPGS NSs (Cur-TPGS NSs). Ultrasonic homogenization (UH) could effectively enhance the solubility of curcumin and to produce homogeneous NSs with small particle sizes. Water solubility of curcumin was significantly improved from 0.6 μg/mL in pure water to 260 μg/mL in the mixture of curcumin and TPGS (1:10) with UH treatment. The mean particle size of Cur-TPGS NSs was decreased significantly after UH and maintained between 208 and 246 nm. Lyophilized powder of Cur-TPGS NSs was dissolved about 91.08% whereas the pristine curcumin powder was dissolved only 6.5% at pH 7.4. This study showed a great potential of Cur-TPGS NSs as a good nano-formulation of curcumin with enhanced solubility and improved oral adsorption.

Original languageEnglish
Pages (from-to)N494-N501
JournalJournal of Food Science
Issue number2
Publication statusPublished - 2016 Feb 1


  • Curcumin
  • Nanosuspensions
  • Solubility
  • TPGS
  • Ultrasonic homogenization

ASJC Scopus subject areas

  • Food Science


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