Enhancement of immunological activity in exo-biopolymer from submerged culture of Lentinus edodes with rice bran

Hwa Young Kim, Jae Taek Han, Seong Gil Hong, Sung Bum Yang, Sung Joo Hwang, Kwang Soon Shin, Hyung Joo Suh, Mi Hyoun Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The objective of the present study was to determine the possible immune-enhancing effects of a substance extracted from a submerged culture of Lentinus edodes with rice bran (SLRB). According to the results obtained by measuring the in vitro macrophage activity of the exo-biopolymer from SLRB, it appears to exhibit activity similar to that of LPS, and this activity seems to occur in a dose-dependent manner. According to the results obtained by measuring splenocyte proliferation, the exo-biopolymer appears to induce an increase in proliferation of approximately 1.4-fold compared to the control group. We measured the proliferation of bone marrow cells in order to evaluate gut immunity and, according to our results, proliferation was increased to 109% that of the control group, and was similar to that associated with LPS. In order to characterize the enhancement of immunological activity in vivo, we orally administered the exo-biopolymer (25, 50, 250 mg/kg bw) to C3H/He mice, and then measured the macrophage activity, determining that the activity was higher than that of the controls at concentrations of 50 and 250 mg/kg. Therefore, the exo-biopolymer from SLRB can be considered to be a useful a BRM agent, as it clearly allows some protection against immunological diseases.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalNatural Product Sciences
Volume11
Issue number3
Publication statusPublished - 2005 Sep

Keywords

  • BRM (biological response modifiers)
  • Immune stimulating activity
  • Lentinus edodes
  • Rice bran

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Kim, H. Y., Han, J. T., Hong, S. G., Yang, S. B., Hwang, S. J., Shin, K. S., Suh, H. J., & Park, M. H. (2005). Enhancement of immunological activity in exo-biopolymer from submerged culture of Lentinus edodes with rice bran. Natural Product Sciences, 11(3), 183-187.