Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast

Kyung Mi Choi, Hye Lan Lee, Young Yon Kwon, Mi Sun Kang, Sung Keun Lee, Cheol-Koo Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume441
Issue number1
DOIs
Publication statusPublished - 2013 Nov 8

Fingerprint

Caloric Restriction
Yeast
Yeasts
Sirolimus
Dapsone
Curcumin
Spermidine
Metformin
Caffeine
Saccharomyces cerevisiae
Aging of materials

Keywords

  • ATP
  • Caloric restriction
  • Caloric restriction mimetics
  • Mitochondrial membrane potential
  • Rapamycin
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast. / Choi, Kyung Mi; Lee, Hye Lan; Kwon, Young Yon; Kang, Mi Sun; Lee, Sung Keun; Lee, Cheol-Koo.

In: Biochemical and Biophysical Research Communications, Vol. 441, No. 1, 08.11.2013, p. 236-242.

Research output: Contribution to journalArticle

@article{53ff0a051b554390969ac334c6b53fce,
title = "Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast",
abstract = "Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process.",
keywords = "ATP, Caloric restriction, Caloric restriction mimetics, Mitochondrial membrane potential, Rapamycin, Reactive oxygen species",
author = "Choi, {Kyung Mi} and Lee, {Hye Lan} and Kwon, {Young Yon} and Kang, {Mi Sun} and Lee, {Sung Keun} and Cheol-Koo Lee",
year = "2013",
month = "11",
day = "8",
doi = "10.1016/j.bbrc.2013.10.049",
language = "English",
volume = "441",
pages = "236--242",
journal = "The BMJ",
issn = "0730-6512",
publisher = "Kluwer Academic Publishers",
number = "1",

}

TY - JOUR

T1 - Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast

AU - Choi, Kyung Mi

AU - Lee, Hye Lan

AU - Kwon, Young Yon

AU - Kang, Mi Sun

AU - Lee, Sung Keun

AU - Lee, Cheol-Koo

PY - 2013/11/8

Y1 - 2013/11/8

N2 - Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process.

AB - Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process.

KW - ATP

KW - Caloric restriction

KW - Caloric restriction mimetics

KW - Mitochondrial membrane potential

KW - Rapamycin

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=84887428133&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887428133&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2013.10.049

DO - 10.1016/j.bbrc.2013.10.049

M3 - Article

C2 - 24141116

AN - SCOPUS:84887428133

VL - 441

SP - 236

EP - 242

JO - The BMJ

JF - The BMJ

SN - 0730-6512

IS - 1

ER -