Enhancement of supercritical CO2 inactivation of spores of Penicillium oxalicum by ethanol cosolvent

Hyong Park Seok, Kyoung Heon Kim

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The inactivation of spores of Penicillium oxalicum by supercritical carbon dioxide (SC-CO2) was optimized by response surface methodology. The optimal inactivation conditions of 16.8 MPa, 49°C, and 20 min were determined using ridge analysis, at which the predicted and experimental log10 reductions were obtained as 5.74 and 6.12, respectively. The synergistic effect of a cosolvent (ethanol), which was used to modify SC-CO2, on the inactivation of the fungal spores was investigated. At less severe conditions of 10 MPa and 40°C, P. oxalicum spores of 107 CFU/ml were completely inactivated within 45 min by SC-CO2 modified with ethanol.

Original languageEnglish
Pages (from-to)833-836
Number of pages4
JournalJournal of microbiology and biotechnology
Issue number6
Publication statusPublished - 2013 Apr 12


  • Cosolvent
  • Ethanol
  • Fungal spores
  • Inactivation
  • Penicillium oxalicum
  • Supercritical carbon dioxide

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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