Enhancing cellular cancer vaccines

Edward P. Cohen, Amla Chopra, Insug O-Sullivan, Tae Sung Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Various strategies have been used to generate cellular cancer vaccines with the expectation that they will become an effective part of the overall management of cancer patients. However, with few notable exceptions, immunization has not resulted in significant long-term therapeutic benefits. Tumor growth has continued and patient survival has been at best only modestly prolonged. One possible explanation is that as only a small proportion of the constituents of malignant cells are 'tumor specific' and the vast majority are the products of nonantigenic, normal 'housekeeping' genes, the immune response in patients immunized with cellular cancer vaccines is not sufficient to result in tumor rejection. Here, we review and characterize various types of cellular cancer vaccines. In addition, in a mouse breast cancer model system, we describe a unique strategy designed to enrich cellular vaccines for cells that induce tumor immunity. Numerous advantages and disadvantages of cancer immunotherapy with cellular vaccines are also presented.

Original languageEnglish
Pages (from-to)495-504
Number of pages10
JournalImmunotherapy
Volume1
Issue number3
DOIs
Publication statusPublished - 2009 Dec 24

Keywords

  • Cancer vaccine
  • Dendritic cell
  • DNA vaccine
  • Enriched vaccine
  • Fibroblast
  • Leukapheresis
  • Tumor DNA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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  • Cite this

    Cohen, E. P., Chopra, A., O-Sullivan, I., & Kim, T. S. (2009). Enhancing cellular cancer vaccines. Immunotherapy, 1(3), 495-504. https://doi.org/10.2217/imt.09.4