Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice

Da Hyun Kim, Woo Chang Chung, Su hyun Chun, Ji Ho Han, Moon Jung Song, Kwang Won Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.

Original languageEnglish
JournalJournal of Dairy Science
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Lactobacillus plantarum
Yogurt
Influenza A virus
natural killer cells
Virus Diseases
yogurt
Natural Killer Cells
influenza
Human Influenza
Hot Temperature
heat
mice
cytokines
infection
Cytokines
Immunity
immunity
respiratory tract diseases
Immune System
public health

Keywords

  • anti-influenza
  • heat-treated Lactobacillus plantarum nF1
  • natural killer cell activity
  • yogurt

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

Cite this

Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice. / Kim, Da Hyun; Chung, Woo Chang; Chun, Su hyun; Han, Ji Ho; Song, Moon Jung; Lee, Kwang Won.

In: Journal of Dairy Science, 01.01.2018.

Research output: Contribution to journalArticle

@article{af0f9e490cee4dfeb4dfd79f5f888c30,
title = "Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice",
abstract = "Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.",
keywords = "anti-influenza, heat-treated Lactobacillus plantarum nF1, natural killer cell activity, yogurt",
author = "Kim, {Da Hyun} and Chung, {Woo Chang} and Chun, {Su hyun} and Han, {Ji Ho} and Song, {Moon Jung} and Lee, {Kwang Won}",
year = "2018",
month = "1",
day = "1",
doi = "10.3168/jds.2018-15137",
language = "English",
journal = "Journal of Dairy Science",
issn = "0022-0302",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice

AU - Kim, Da Hyun

AU - Chung, Woo Chang

AU - Chun, Su hyun

AU - Han, Ji Ho

AU - Song, Moon Jung

AU - Lee, Kwang Won

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.

AB - Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.

KW - anti-influenza

KW - heat-treated Lactobacillus plantarum nF1

KW - natural killer cell activity

KW - yogurt

UR - http://www.scopus.com/inward/record.url?scp=85054466206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054466206&partnerID=8YFLogxK

U2 - 10.3168/jds.2018-15137

DO - 10.3168/jds.2018-15137

M3 - Article

C2 - 30316596

AN - SCOPUS:85054466206

JO - Journal of Dairy Science

JF - Journal of Dairy Science

SN - 0022-0302

ER -