eNOS3 genetic polymorphism is related to post-ablation early recurrence of atrial fibrillation

Jaemin Shim, Jae Hyung Park, Ji Young Lee, Jae Sun Uhm, Boyoung Joung, Moon Hyoung Lee, Patrick T. Ellinor, Hui Nam Pak

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA). Materials and Methods: A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines. Results: The frequencies of the rs1799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95% CI 0.75–1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8% and 24.8%, respectively. The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06–2.79, p=0.028), but not with CR. ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95% CI 1.07–2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation. Conclusion: The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.

Original languageEnglish
Pages (from-to)1244-1250
Number of pages7
JournalYonsei Medical Journal
Volume56
Issue number5
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Genetic Polymorphisms
Atrial Fibrillation
Recurrence
Catheter Ablation
Alleles
Genes
Single Nucleotide Polymorphism
Coronary Artery Disease
Logistic Models
Stroke
Regression Analysis
Guidelines
Control Groups

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • eNOS gene
  • Recurrence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

eNOS3 genetic polymorphism is related to post-ablation early recurrence of atrial fibrillation. / Shim, Jaemin; Park, Jae Hyung; Lee, Ji Young; Uhm, Jae Sun; Joung, Boyoung; Lee, Moon Hyoung; Ellinor, Patrick T.; Pak, Hui Nam.

In: Yonsei Medical Journal, Vol. 56, No. 5, 01.01.2015, p. 1244-1250.

Research output: Contribution to journalArticle

Shim, J, Park, JH, Lee, JY, Uhm, JS, Joung, B, Lee, MH, Ellinor, PT & Pak, HN 2015, 'eNOS3 genetic polymorphism is related to post-ablation early recurrence of atrial fibrillation', Yonsei Medical Journal, vol. 56, no. 5, pp. 1244-1250. https://doi.org/10.3349/ymj.2015.56.5.1244
Shim, Jaemin ; Park, Jae Hyung ; Lee, Ji Young ; Uhm, Jae Sun ; Joung, Boyoung ; Lee, Moon Hyoung ; Ellinor, Patrick T. ; Pak, Hui Nam. / eNOS3 genetic polymorphism is related to post-ablation early recurrence of atrial fibrillation. In: Yonsei Medical Journal. 2015 ; Vol. 56, No. 5. pp. 1244-1250.
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abstract = "Purpose: Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA). Materials and Methods: A total of 500 consecutive patients (56±11 years, 77{\%} male) with paroxysmal (68{\%}) or persistent (32{\%}) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines. Results: The frequencies of the rs1799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95{\%} CI 0.75–1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0{\%} vs. 17.3{\%}, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8{\%} and 24.8{\%}, respectively. The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95{\%} CI 1.06–2.79, p=0.028), but not with CR. ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95{\%} CI 1.07–2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation. Conclusion: The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.",
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AU - Uhm, Jae Sun

AU - Joung, Boyoung

AU - Lee, Moon Hyoung

AU - Ellinor, Patrick T.

AU - Pak, Hui Nam

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N2 - Purpose: Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA). Materials and Methods: A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines. Results: The frequencies of the rs1799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95% CI 0.75–1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8% and 24.8%, respectively. The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06–2.79, p=0.028), but not with CR. ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95% CI 1.07–2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation. Conclusion: The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.

AB - Purpose: Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA). Materials and Methods: A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines. Results: The frequencies of the rs1799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95% CI 0.75–1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8% and 24.8%, respectively. The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06–2.79, p=0.028), but not with CR. ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95% CI 1.07–2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation. Conclusion: The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.

KW - Atrial fibrillation

KW - Catheter ablation

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KW - Recurrence

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