eNOS3 genetic polymorphism is related to post-ablation early recurrence of atrial fibrillation

Jaemin Shim, Jae Hyung Park, Ji Young Lee, Jae Sun Uhm, Boyoung Joung, Moon Hyoung Lee, Patrick T. Ellinor, Hui Nam Pak

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6 Citations (Scopus)

Abstract

Purpose: Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA). Materials and Methods: A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines. Results: The frequencies of the rs1799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95% CI 0.75–1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8% and 24.8%, respectively. The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06–2.79, p=0.028), but not with CR. ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95% CI 1.07–2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation. Conclusion: The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.

Original languageEnglish
Pages (from-to)1244-1250
Number of pages7
JournalYonsei Medical Journal
Volume56
Issue number5
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • eNOS gene
  • Recurrence

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Shim, J., Park, J. H., Lee, J. Y., Uhm, J. S., Joung, B., Lee, M. H., Ellinor, P. T., & Pak, H. N. (2015). eNOS3 genetic polymorphism is related to post-ablation early recurrence of atrial fibrillation. Yonsei Medical Journal, 56(5), 1244-1250. https://doi.org/10.3349/ymj.2015.56.5.1244