ent-Kaurane diterpenoids from Isodon japonicus

Seong Su Hong, Seon A. Lee, Xiang Hua Han, Ji Sang Hwang, Chul Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Heesoon Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Five ent-kaurane diterpenoids, 6β,7β,14β-trihydroxy- 1α,19-diacetoxy-7α,20-epoxy-ent-kaur-16-en-15-one (1), 1α,6β,7β-trihydroxy-11α,19-diacetoxy-7α, 20-epoxy-ent-kaur-16-en-15-one (2), 6-hydroxy-1α,19-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (3), 19-hydroxy-1α,6-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (4), and 6-aldehyde1α,19-diacetoxy-6,7- seco-ent-kaur-16-en-15-one-7,20-olide (5), along with 10 known ent-kaurane diterpenoids, pseurata C (6), longikaurin C (7), effusanin C (8), longikaurin B (9), longikaurin D (10), effusanin D (11), excisanin B (12), lasiokaurin (13), megathyrin A (14), and loxothyrin A (15), were isolated from the aerial parts of Isodon japonicus. Their structures were determined on the basis of spectroscopic (1D-, 2D-NMR and MS) and chemical evidence. The isolates were evaluated for their inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells.

Original languageEnglish
Pages (from-to)1055-1058
Number of pages4
JournalJournal of Natural Products
Volume71
Issue number6
DOIs
Publication statusPublished - 2008 Jun 1

Fingerprint

Isodon
Kaurane Diterpenes
Diterpenes
epoxides
diterpenoids
Macrophages
aerial parts
nitric oxide
Nitric Oxide
macrophages
Nuclear magnetic resonance
Antennas
mice
cells

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Hong, S. S., Lee, S. A., Han, X. H., Hwang, J. S., Lee, C., Lee, D., ... Hwang, B. Y. (2008). ent-Kaurane diterpenoids from Isodon japonicus. Journal of Natural Products, 71(6), 1055-1058. https://doi.org/10.1021/np0705965

ent-Kaurane diterpenoids from Isodon japonicus. / Hong, Seong Su; Lee, Seon A.; Han, Xiang Hua; Hwang, Ji Sang; Lee, Chul; Lee, Dongho; Hong, Jin Tae; Kim, Youngsoo; Lee, Heesoon; Hwang, Bang Yeon.

In: Journal of Natural Products, Vol. 71, No. 6, 01.06.2008, p. 1055-1058.

Research output: Contribution to journalArticle

Hong, SS, Lee, SA, Han, XH, Hwang, JS, Lee, C, Lee, D, Hong, JT, Kim, Y, Lee, H & Hwang, BY 2008, 'ent-Kaurane diterpenoids from Isodon japonicus', Journal of Natural Products, vol. 71, no. 6, pp. 1055-1058. https://doi.org/10.1021/np0705965
Hong SS, Lee SA, Han XH, Hwang JS, Lee C, Lee D et al. ent-Kaurane diterpenoids from Isodon japonicus. Journal of Natural Products. 2008 Jun 1;71(6):1055-1058. https://doi.org/10.1021/np0705965
Hong, Seong Su ; Lee, Seon A. ; Han, Xiang Hua ; Hwang, Ji Sang ; Lee, Chul ; Lee, Dongho ; Hong, Jin Tae ; Kim, Youngsoo ; Lee, Heesoon ; Hwang, Bang Yeon. / ent-Kaurane diterpenoids from Isodon japonicus. In: Journal of Natural Products. 2008 ; Vol. 71, No. 6. pp. 1055-1058.
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abstract = "Five ent-kaurane diterpenoids, 6β,7β,14β-trihydroxy- 1α,19-diacetoxy-7α,20-epoxy-ent-kaur-16-en-15-one (1), 1α,6β,7β-trihydroxy-11α,19-diacetoxy-7α, 20-epoxy-ent-kaur-16-en-15-one (2), 6-hydroxy-1α,19-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (3), 19-hydroxy-1α,6-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (4), and 6-aldehyde1α,19-diacetoxy-6,7- seco-ent-kaur-16-en-15-one-7,20-olide (5), along with 10 known ent-kaurane diterpenoids, pseurata C (6), longikaurin C (7), effusanin C (8), longikaurin B (9), longikaurin D (10), effusanin D (11), excisanin B (12), lasiokaurin (13), megathyrin A (14), and loxothyrin A (15), were isolated from the aerial parts of Isodon japonicus. Their structures were determined on the basis of spectroscopic (1D-, 2D-NMR and MS) and chemical evidence. The isolates were evaluated for their inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells.",
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AB - Five ent-kaurane diterpenoids, 6β,7β,14β-trihydroxy- 1α,19-diacetoxy-7α,20-epoxy-ent-kaur-16-en-15-one (1), 1α,6β,7β-trihydroxy-11α,19-diacetoxy-7α, 20-epoxy-ent-kaur-16-en-15-one (2), 6-hydroxy-1α,19-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (3), 19-hydroxy-1α,6-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (4), and 6-aldehyde1α,19-diacetoxy-6,7- seco-ent-kaur-16-en-15-one-7,20-olide (5), along with 10 known ent-kaurane diterpenoids, pseurata C (6), longikaurin C (7), effusanin C (8), longikaurin B (9), longikaurin D (10), effusanin D (11), excisanin B (12), lasiokaurin (13), megathyrin A (14), and loxothyrin A (15), were isolated from the aerial parts of Isodon japonicus. Their structures were determined on the basis of spectroscopic (1D-, 2D-NMR and MS) and chemical evidence. The isolates were evaluated for their inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells.

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