Enzyme-triggered cascade reactions and assembly of abiotic block copolymers into micellar nanostructures

Jingyi Rao, Christine Hottinger, Anzar Khan

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Catalytic action of an enzyme is shown to transform a non-assembling block copolymer, composed of a completely non-natural repeat unit structure, into a self-assembling polymer building block. To achieve this, poly(styrene) is combined with an enzyme-sensitive methacrylate-based polymer segment carrying carefully designed azobenzene side chains. Once exposed to the enzyme azoreductase, in the presence of coenzyme NADPH, the azobenzene linkages undergo a bond scission reaction. This triggers a spontaneous 1,6-self-elimination cascade process and transforms the initially hydrophobic methacrylate polymer segment into a hydrophilic hydroxyethyl methacrylate structure. This change in chemical polarity of one of the polymer blocks confers an amphiphilic character to the diblock copolymer and permits it to self-assemble into a micellar nanostructure in water.

Original languageEnglish
Pages (from-to)5872-5875
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number16
DOIs
Publication statusPublished - 2014 Apr 23
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Enzyme-triggered cascade reactions and assembly of abiotic block copolymers into micellar nanostructures'. Together they form a unique fingerprint.

  • Cite this