EORTC QLQ-C15-PAL quality of life score as a prognostic indicator of survival in patients with far advanced cancer

Yong Joo Lee, Sang Yeon Suh, Youn Seon Choi, Jae Yong Shim, Ah Ram Seo, Sung Eun Choi, Hong Yup Ahn, Eunji Yim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: Quality of life (QoL) and performance status predict survival in advanced cancer patients; these relationships have not been explored in the hospice palliative care setting. The aim of this study was to examine the survival predictability of patient-reported QoL using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C15-PAL questionnaire in far advanced cancer inpatients at the very end of life. Methods: This is a retrospective cohort study. Patients reported QoL using the EORTC QLQ-C15-PAL. One hundred sixty-two inpatients in hospice palliative wards of six hospitals in South Korea were followed until death or the end of the study. Additional symptoms and performance status were assessed by the MD Anderson Symptom Inventory - Korean (MDASI-K), Palliative Performance Scale (PPS) and Eastern Cooperative Oncology Group (ECOG) performance status. Correlations between EORTC QLQ-C15-PAL, MDASI-K, PPS, and ECOG were assessed. Survival analyses were performed using Cox proportional hazard models. Results: Patients' median survival was less than 1 month. Physician-reported PPS significantly predicted survival (hazard ratio [HR] 0.493; p<0.001). From the EORTC QLQ-C15-PAL, patient-reported physical functioning predicted survival (HR=0.65; p<0.001). Other six domains of EORTC QLQ-C15-PAL were significantly related to survival after adjustment. Those domains were global health status, emotional functioning, fatigue, nausea/vomiting, appetite loss, and constipation. Conclusions: EORTC QLQ-C15-PAL can be an independent prognostic factor in inpatients with far advanced cancer. Patient-reported physical functioning showed survival predictability as good as physician-reported performance status. It is notable that the QLQ instrument is useful even for patients in their final month of life. Cancer anorexia-cachexia syndrome-related symptoms may be independent prognostic symptoms. Prospective study is warranted.

Original languageEnglish
Pages (from-to)1941-1948
Number of pages8
JournalSupportive Care in Cancer
Volume22
Issue number7
DOIs
Publication statusPublished - 2014 Jan 1

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Quality of Life
Organizations
Survival
Research
Neoplasms
Therapeutics
Inpatients
Physicians
Social Adjustment
Hospice Care
Equipment and Supplies
Republic of Korea
Cachexia
Hospices
Anorexia
Appetite
Constipation
Survival Analysis
Palliative Care
Proportional Hazards Models

Keywords

  • EORTC QLQ-C15-PAL
  • Palliative care
  • Performance status
  • Quality of life
  • Survival

ASJC Scopus subject areas

  • Oncology

Cite this

EORTC QLQ-C15-PAL quality of life score as a prognostic indicator of survival in patients with far advanced cancer. / Lee, Yong Joo; Suh, Sang Yeon; Choi, Youn Seon; Shim, Jae Yong; Seo, Ah Ram; Choi, Sung Eun; Ahn, Hong Yup; Yim, Eunji.

In: Supportive Care in Cancer, Vol. 22, No. 7, 01.01.2014, p. 1941-1948.

Research output: Contribution to journalArticle

Lee, Yong Joo ; Suh, Sang Yeon ; Choi, Youn Seon ; Shim, Jae Yong ; Seo, Ah Ram ; Choi, Sung Eun ; Ahn, Hong Yup ; Yim, Eunji. / EORTC QLQ-C15-PAL quality of life score as a prognostic indicator of survival in patients with far advanced cancer. In: Supportive Care in Cancer. 2014 ; Vol. 22, No. 7. pp. 1941-1948.
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T1 - EORTC QLQ-C15-PAL quality of life score as a prognostic indicator of survival in patients with far advanced cancer

AU - Lee, Yong Joo

AU - Suh, Sang Yeon

AU - Choi, Youn Seon

AU - Shim, Jae Yong

AU - Seo, Ah Ram

AU - Choi, Sung Eun

AU - Ahn, Hong Yup

AU - Yim, Eunji

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: Quality of life (QoL) and performance status predict survival in advanced cancer patients; these relationships have not been explored in the hospice palliative care setting. The aim of this study was to examine the survival predictability of patient-reported QoL using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C15-PAL questionnaire in far advanced cancer inpatients at the very end of life. Methods: This is a retrospective cohort study. Patients reported QoL using the EORTC QLQ-C15-PAL. One hundred sixty-two inpatients in hospice palliative wards of six hospitals in South Korea were followed until death or the end of the study. Additional symptoms and performance status were assessed by the MD Anderson Symptom Inventory - Korean (MDASI-K), Palliative Performance Scale (PPS) and Eastern Cooperative Oncology Group (ECOG) performance status. Correlations between EORTC QLQ-C15-PAL, MDASI-K, PPS, and ECOG were assessed. Survival analyses were performed using Cox proportional hazard models. Results: Patients' median survival was less than 1 month. Physician-reported PPS significantly predicted survival (hazard ratio [HR] 0.493; p<0.001). From the EORTC QLQ-C15-PAL, patient-reported physical functioning predicted survival (HR=0.65; p<0.001). Other six domains of EORTC QLQ-C15-PAL were significantly related to survival after adjustment. Those domains were global health status, emotional functioning, fatigue, nausea/vomiting, appetite loss, and constipation. Conclusions: EORTC QLQ-C15-PAL can be an independent prognostic factor in inpatients with far advanced cancer. Patient-reported physical functioning showed survival predictability as good as physician-reported performance status. It is notable that the QLQ instrument is useful even for patients in their final month of life. Cancer anorexia-cachexia syndrome-related symptoms may be independent prognostic symptoms. Prospective study is warranted.

AB - Purpose: Quality of life (QoL) and performance status predict survival in advanced cancer patients; these relationships have not been explored in the hospice palliative care setting. The aim of this study was to examine the survival predictability of patient-reported QoL using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C15-PAL questionnaire in far advanced cancer inpatients at the very end of life. Methods: This is a retrospective cohort study. Patients reported QoL using the EORTC QLQ-C15-PAL. One hundred sixty-two inpatients in hospice palliative wards of six hospitals in South Korea were followed until death or the end of the study. Additional symptoms and performance status were assessed by the MD Anderson Symptom Inventory - Korean (MDASI-K), Palliative Performance Scale (PPS) and Eastern Cooperative Oncology Group (ECOG) performance status. Correlations between EORTC QLQ-C15-PAL, MDASI-K, PPS, and ECOG were assessed. Survival analyses were performed using Cox proportional hazard models. Results: Patients' median survival was less than 1 month. Physician-reported PPS significantly predicted survival (hazard ratio [HR] 0.493; p<0.001). From the EORTC QLQ-C15-PAL, patient-reported physical functioning predicted survival (HR=0.65; p<0.001). Other six domains of EORTC QLQ-C15-PAL were significantly related to survival after adjustment. Those domains were global health status, emotional functioning, fatigue, nausea/vomiting, appetite loss, and constipation. Conclusions: EORTC QLQ-C15-PAL can be an independent prognostic factor in inpatients with far advanced cancer. Patient-reported physical functioning showed survival predictability as good as physician-reported performance status. It is notable that the QLQ instrument is useful even for patients in their final month of life. Cancer anorexia-cachexia syndrome-related symptoms may be independent prognostic symptoms. Prospective study is warranted.

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