Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: A prospective observational study in 12 university hospitals in Korea

Dae Won Park, Byung Chul Chunx, June Myung Kim, Jang Wook Sohn, Kyong Ran Peck, Yang Soo Kim, Young Hwa Choi, Jun Yong Choi, Sang Il Kim, Joong Sik Eom, Hyo Youl Kim, Joon-Young Song, Young Goo Song, Hee Jung Choi, Ja Kim Min

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis and septic shock. Subjects included 1,192 adult patients admitted to the 22 participating intensive care units (ICUs) of 12 university hospitals in the Korean Sepsis Registry System from April, 2005 through February, 2009. Male accounted for 656 (55%) patients. Mean age was 65.0 ± 14.2 yr. Septic shock developed in 740 (62.1%) patients. Bacteremia was present in 422 (35.4%) patients. The 28-day and in-hospital mortality rates were 23.0% and 28.0%, respectively. Men were more likely to have comorbid illnesses and acute organ dysfunctions, and had higher mortality and clinical severity compared to women. While respiratory sources of sepsis were common in men, urinary sources were predominant in women. In the multivariate logistic regression analysis, cancer (odds ratio 1.89; 95% confidence interval 1.13-3.17), urinary tract infection (0.25; 0.13-0.46), APACHE II score (1.05; 1.02-1.09), SOFA score on day 1 (1.13; 1.06-1.21) and metabolic dysfunction (2.24, 1.45-3.45) were independent clinical factors for gender-related in-hospital mortality. This study provided epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock in ICUs in Korea, and demonstrated the impact of clinical factors on gender difference in mortality.

Original languageEnglish
Pages (from-to)1308-1314
Number of pages7
JournalJournal of Korean Medical Science
Volume27
Issue number11
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

Fingerprint

Korea
Septic Shock
Observational Studies
Sepsis
Prospective Studies
Hospital Mortality
Intensive Care Units
Mortality
APACHE
Bacteremia
Urinary Tract Infections
Multicenter Studies
Registries
Epidemiologic Studies
Epidemiology
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Neoplasms

Keywords

  • Epidemiology
  • Gender
  • Mortality
  • Risk factor
  • Septic shock
  • Severe sepsis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock : A prospective observational study in 12 university hospitals in Korea. / Park, Dae Won; Chunx, Byung Chul; Kim, June Myung; Sohn, Jang Wook; Peck, Kyong Ran; Kim, Yang Soo; Choi, Young Hwa; Choi, Jun Yong; Kim, Sang Il; Eom, Joong Sik; Kim, Hyo Youl; Song, Joon-Young; Song, Young Goo; Choi, Hee Jung; Min, Ja Kim.

In: Journal of Korean Medical Science, Vol. 27, No. 11, 01.12.2012, p. 1308-1314.

Research output: Contribution to journalArticle

Park, Dae Won ; Chunx, Byung Chul ; Kim, June Myung ; Sohn, Jang Wook ; Peck, Kyong Ran ; Kim, Yang Soo ; Choi, Young Hwa ; Choi, Jun Yong ; Kim, Sang Il ; Eom, Joong Sik ; Kim, Hyo Youl ; Song, Joon-Young ; Song, Young Goo ; Choi, Hee Jung ; Min, Ja Kim. / Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock : A prospective observational study in 12 university hospitals in Korea. In: Journal of Korean Medical Science. 2012 ; Vol. 27, No. 11. pp. 1308-1314.
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AU - Sohn, Jang Wook

AU - Peck, Kyong Ran

AU - Kim, Yang Soo

AU - Choi, Young Hwa

AU - Choi, Jun Yong

AU - Kim, Sang Il

AU - Eom, Joong Sik

AU - Kim, Hyo Youl

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