Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: A prospective observational study in 12 university hospitals in Korea

Dae Won Park, Byung Chul Chunx, June Myung Kim, Jang Wook Sohn, Kyong Ran Peck, Yang Soo Kim, Young Hwa Choi, Jun Yong Choi, Sang Il Kim, Joong Sik Eom, Hyo Youl Kim, Joon Young Song, Young Goo Song, Hee Jung Choi, Min Ja Kim

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A prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis and septic shock. Subjects included 1,192 adult patients admitted to the 22 participating intensive care units (ICUs) of 12 university hospitals in the Korean Sepsis Registry System from April, 2005 through February, 2009. Male accounted for 656 (55%) patients. Mean age was 65.0 ± 14.2 yr. Septic shock developed in 740 (62.1%) patients. Bacteremia was present in 422 (35.4%) patients. The 28-day and in-hospital mortality rates were 23.0% and 28.0%, respectively. Men were more likely to have comorbid illnesses and acute organ dysfunctions, and had higher mortality and clinical severity compared to women. While respiratory sources of sepsis were common in men, urinary sources were predominant in women. In the multivariate logistic regression analysis, cancer (odds ratio 1.89; 95% confidence interval 1.13-3.17), urinary tract infection (0.25; 0.13-0.46), APACHE II score (1.05; 1.02-1.09), SOFA score on day 1 (1.13; 1.06-1.21) and metabolic dysfunction (2.24, 1.45-3.45) were independent clinical factors for gender-related in-hospital mortality. This study provided epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock in ICUs in Korea, and demonstrated the impact of clinical factors on gender difference in mortality.

Original languageEnglish
Pages (from-to)1308-1314
Number of pages7
JournalJournal of Korean medical science
Issue number11
Publication statusPublished - 2012 Dec 1



  • Epidemiology
  • Gender
  • Mortality
  • Risk factor
  • Septic shock
  • Severe sepsis

ASJC Scopus subject areas

  • Medicine(all)

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